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Toxins
Volume 14
Issue 1
10.3390/toxins14010036
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Review
Peer-Review Record

A Systematic Review and Meta-Analysis of Efficacy of Botulinum Toxin A for Neuropathic Pain

Toxins 2022, 14(1), 36; https://doi.org/10.3390/toxins14010036
by Anupam Datta Gupta 1,*, Suzanne Edwards 2, Jessica Smith 1, John Snow 3, Renuka Visvanathan 4, Graeme Tucker 4 and David Wilson 4
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Toxins 2022, 14(1), 36; https://doi.org/10.3390/toxins14010036
Submission received: 14 December 2021 / Revised: 27 December 2021 / Accepted: 29 December 2021 / Published: 3 January 2022
(This article belongs to the Section Bacterial Toxins)

Round 1

Reviewer 1 Report

Thank you for submitting your manuscript "A Systematic Review and Meta-analysis of Efficacy of Botulinum Toxin A for Neuropathic Pain" to the Toxins. This manuscript well describes effectiveness and evidence of BoNT-A treatment for neuropathic pain systematically.

This manuscript is a very well organized and excellently described paper.

It has scientific soundness, novelty and least self-recommendations.

English level is also good.

I think it is appropriate for publication in Toxins if it will be revised minorly.

 

Specific comments:

  1. Please check minor spells as below…

Ex: In page 1, line 17 : BoNTA,

       In page 2, line 63 : BTX-X,

       In page 4, line 116 : BONT-A,

       In page 10, line 234 : question/s

  1. Please modify Figure 2.

 

 

Thank you!

Sincerely,

Reviewer

 

Author Response

Please note that I have changed the following spellings as advised by Reviewer 1

       In page 1, line 17 : BoNTA- changed to BoNT-A,

       In page 2, line 63 : BTX-X -changed to BoNT-A,

       In page 4, line 116 : BONT-A-changed to BoNT-A,

       In page 10, line 234 : question/s- changed to questions

  1. Figure 2- modified.

Reviewer 2 Report

This brief review evaluates the potential therapeutic benefit of botulinum toxin A (BTX) in the neuropathic pain. This study analyzed randomized control trials (RCTs) from 2005 to 2021. They concluded BTX displays therapeutic effect in neuropathic pain with satisfied safety and without notable side effects. Nevertheless, more clinical trial is necessary for widely clinical usage.

 

MAJOR COMMENTS

  1. The aim of this study is clear and straightforward, and the result is valuable in developing a medical strategy for relieving neuropathic pain.
  2. Even though the conclusion of this study is that BTX effectively relieves neuropathic pain, yet the detailed information about the latency of effect as well as the cost of treatment is necessary for public health decisions.

Author Response

We agree with the reviewer's comment about the latency of effect as well as the cost of treatment are required for public health decisions. We have included this in the main manuscript body.

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