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Article

Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage

1
Centre of Excellence in New Target Discovery (CENTD), Butantan Institute, Butantã 05503-900, SP, Brazil
2
Development and Innovation Department, Butantan Institute, Butantã 05503-900, SP, Brazil
3
Biochemistry Department, Federal University of São Paulo, Vila Clementino 04044-020, SP, Brazil
*
Author to whom correspondence should be addressed.
Toxins 2021, 13(7), 462; https://doi.org/10.3390/toxins13070462
Received: 26 May 2021 / Revised: 26 June 2021 / Accepted: 28 June 2021 / Published: 30 June 2021
(This article belongs to the Section Animal Venoms)
Envenomation caused by contact with Lonomia obliqua bristles is characterized by pain, an intense systemic proinflammatory reaction and disturbances in the coagulation cascade that can cause severe clinical manifestations and death. However, the role of immune system components in these effects is still poorly understood. In this study, we evaluated the cytotoxic effect of L. obliqua venom on THP-1-derived macrophages and its ability to modulate inflammatory markers, as well as the cytokine and chemokine release profile. Our results show that L. obliqua venom is able to directly exert a potent pro-inflammatory reaction in macrophages, characterized by the activation of the NF-κB transcription factor pathway, the expression of CD80 and CD83, and the release of pro-inflammatory mediators such as TNF-α, IL-1β, IL-6, IL-8 and CXCL10. These results suggest that macrophages can play an important role during the orchestration of the inflammatory response present in envenomation caused by Lonomia obliqua caterpillars. View Full-Text
Keywords: Lonomia obliqua; inflammation; macrophage activation Lonomia obliqua; inflammation; macrophage activation
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MDPI and ACS Style

Oliveira, D.S.; de Souza, J.G.; Alvarez-Flores, M.P.; Cunegundes, P.S.; DeOcesano-Pereira, C.; Lobba, A.M.; Gomes, R.N.; Chudzinski-Tavassi, A.M. Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage. Toxins 2021, 13, 462. https://doi.org/10.3390/toxins13070462

AMA Style

Oliveira DS, de Souza JG, Alvarez-Flores MP, Cunegundes PS, DeOcesano-Pereira C, Lobba AM, Gomes RN, Chudzinski-Tavassi AM. Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage. Toxins. 2021; 13(7):462. https://doi.org/10.3390/toxins13070462

Chicago/Turabian Style

Oliveira, Douglas S., Jean G. de Souza, Miryam P. Alvarez-Flores, Priscila S. Cunegundes, Carlos DeOcesano-Pereira, Aline M. Lobba, Renata N. Gomes, and Ana M. Chudzinski-Tavassi. 2021. "Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage" Toxins 13, no. 7: 462. https://doi.org/10.3390/toxins13070462

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