Next Article in Journal
A Fumonisin Prevention Tool for Targeting and Ranking Agroclimatic Conditions Favoring Exposure in French Maize-Growing Areas
Previous Article in Journal
Occurrence and Toxicogenetic Profiling of Clostridium perfringens in Buffalo and Cattle: An Update from Pakistan
Review

Botulinum Toxin A and Osteosarcopenia in Experimental Animals: A Scoping Review

1
Department of Orthopaedics, The Royal Children’s Hospital, Parkville, VIC 3052, Australia
2
Department of Paediatrics, University of Melbourne, Parkville, VIC 3010, Australia
3
Department of Orthopedics, Shriners Hospitals for Children, Chicago, IL 60707, USA
*
Author to whom correspondence should be addressed.
Toxins 2021, 13(3), 213; https://doi.org/10.3390/toxins13030213
Received: 23 February 2021 / Revised: 11 March 2021 / Accepted: 11 March 2021 / Published: 14 March 2021
(This article belongs to the Section Bacterial Toxins)
We conducted a scoping review to investigate the effects of intramuscular injection of Botulinum Toxin A (BoNT-A) on bone morphology. We investigated if the muscle atrophy associated with Injection of BoNT-A had effects on the neighboring bone. We used the search terms: osteopenia, bone atrophy, Botulinum Toxin A, Micro-CT, mice or rat. The following databases were searched: Medline, Embase, PubMed and the Cochrane Library, between 1990 and 2020. After removal of duplicates, 228 abstracts were identified of which 49 studies satisfied our inclusion and exclusion criteria. The majority of studies (41/49) reported a quantitative reduction in at least one measure of bone architecture based on Micro-CT. The reduction in the ratio of bone volume to tissue volume varied from 11% to 81% (mean 43%) according to the experimental set up and study time points. While longer term studies showed muscle recovery, no study showed complete recovery of all bone properties at the termination of the study. In experimental animals, intramuscular injection of BoNT-A resulted in acute muscle atrophy and acute degradation of the neighboring bone segment. These findings may have implications for clinical protocols in the use of Botulinum Toxin in children with cerebral palsy, with restraint recommended in injection protocols and consideration for monitoring bone density. Clinical studies in children with cerebral palsy receiving injections of Botulinum are indicated. View Full-Text
Keywords: Botulinum Toxin A; muscle atrophy; sarcopenia; osteopenia; experimental animals; cerebral palsy Botulinum Toxin A; muscle atrophy; sarcopenia; osteopenia; experimental animals; cerebral palsy
Show Figures

Figure 1

MDPI and ACS Style

Tang, M.J.; Graham, H.K.; Davidson, K.E. Botulinum Toxin A and Osteosarcopenia in Experimental Animals: A Scoping Review. Toxins 2021, 13, 213. https://doi.org/10.3390/toxins13030213

AMA Style

Tang MJ, Graham HK, Davidson KE. Botulinum Toxin A and Osteosarcopenia in Experimental Animals: A Scoping Review. Toxins. 2021; 13(3):213. https://doi.org/10.3390/toxins13030213

Chicago/Turabian Style

Tang, Min J., H. K. Graham, and Kelsey E. Davidson. 2021. "Botulinum Toxin A and Osteosarcopenia in Experimental Animals: A Scoping Review" Toxins 13, no. 3: 213. https://doi.org/10.3390/toxins13030213

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop