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Botulinum Neurotoxin Injections in Childhood Opisthotonus

1
Section of Pediatric Neurology and Developmental Neuroscience, Texas Children’s Hospital and Baylor College of Medicine, Houston, TX 77030, USA
2
Parkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Toxins 2021, 13(2), 137; https://doi.org/10.3390/toxins13020137
Received: 25 January 2021 / Revised: 5 February 2021 / Accepted: 10 February 2021 / Published: 12 February 2021
(This article belongs to the Special Issue Botulinum Toxins: An Application in Humans and Animals)
Opisthotonus refers to abnormal axial extension and arching of the trunk produced by excessive contractions of the paraspinal muscles. In childhood, the abnormal posture is most often related to dystonia in the setting of hypoxic injury or a number of other acquired and genetic etiologies. The condition is often painful, interferes with ambulation and quality of life, and is challenging to treat. Therapeutic options include oral benzodiazepines, oral and intrathecal baclofen, botulinum neurotoxin injections, and deep brain stimulation. Management of opisthotonus within the pediatric population has not been systematically reviewed. Here, we describe a series of seven children who presented to our institution with opisthotonus in whom symptom relief was achieved following administration of botulinum neurotoxin injections. View Full-Text
Keywords: opisthotonus; opisthotonos; axial dystonia; botulinum toxin opisthotonus; opisthotonos; axial dystonia; botulinum toxin
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MDPI and ACS Style

Hull, M.; Parnes, M.; Jankovic, J. Botulinum Neurotoxin Injections in Childhood Opisthotonus. Toxins 2021, 13, 137. https://doi.org/10.3390/toxins13020137

AMA Style

Hull M, Parnes M, Jankovic J. Botulinum Neurotoxin Injections in Childhood Opisthotonus. Toxins. 2021; 13(2):137. https://doi.org/10.3390/toxins13020137

Chicago/Turabian Style

Hull, Mariam, Mered Parnes, and Joseph Jankovic. 2021. "Botulinum Neurotoxin Injections in Childhood Opisthotonus" Toxins 13, no. 2: 137. https://doi.org/10.3390/toxins13020137

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