Special Issue: Immune Dysfunction in Uremia
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References
- Vanholder, R.; De Smet, R.; Glorieux, G.; Argiles, A.; Baurmeister, U.; Brunet, P.; Clark, W.; Cohen, G.; De Deyn, P.P.; Deppisch, R.; et al. Review on uremic toxins: Classification, concentration, and interindividual variability. Kidney Int. 2003, 63, 1934–1943. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Cohen, G. Immune Dysfunction in Uremia 2020. Toxins (Basel) 2020, 12, 439. [Google Scholar] [CrossRef] [PubMed]
- Jeng, Y.; Lim, P.S.; Wu, M.Y.; Tseng, T.Y.; Chen, C.H.; Chen, H.P.; Wu, T.K. Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients. Mediat. Inflamm. 2017, 2017, 1070959. [Google Scholar] [CrossRef]
- Girndt, M.; Trojanowicz, B.; Ulrich, C. Monocytes in Uremia. Toxins (Basel) 2020, 12, 340. [Google Scholar] [CrossRef]
- Betjes, M.G. Immune cell dysfunction and inflammation in end-stage renal disease. Nat. Rev. Nephrol. 2013, 9, 255–265. [Google Scholar] [CrossRef] [PubMed]
- Betjes, M.G. Uremia-Associated Ageing of the Thymus and Adaptive Immune Responses. Toxins (Basel) 2020, 12, 224. [Google Scholar] [CrossRef] [Green Version]
- Dounousi, E.; Papavasiliou, E.; Makedou, A.; Ioannou, K.; Katopodis, K.P.; Tselepis, A.; Siamopoulos, K.C.; Tsakiris, D. Oxidative stress is progressively enhanced with advancing stages of CKD. Am. J. Kidney Dis. 2006, 48, 752–760. [Google Scholar] [CrossRef] [Green Version]
- Suvakov, S.; Jerotic, D.; Damjanovic, T.; Milic, N.; Pekmezovic, T.; Djukic, T.; Jelic-Ivanovic, Z.; Savic Radojevic, A.; Pljesa-Ercegovac, M.; Matic, M.; et al. Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival. Am. J. Nephrol. 2019, 50, 115–125. [Google Scholar] [CrossRef]
- Morena, M.; Cristol, J.P.; Senecal, L.; Leray-Moragues, H.; Krieter, D.; Canaud, B. Oxidative stress in hemodialysis patients: Is NADPH oxidase complex the culprit? Kidney Int. Suppl. 2002, 80, 109–114. [Google Scholar] [CrossRef] [Green Version]
- Jerotic, D.; Matic, M.; Suvakov, S.; Vucicevic, K.; Damjanovic, T.; Savic-Radojevic, A.; Pljesa-Ercegovac, M.; Coric, V.; Stefanovic, A.; Ivanisevic, J.; et al. Association of Nrf2, SOD2 and GPX1 Polymorphisms with Biomarkers of Oxidative Distress and Survival in End-Stage Renal Disease Patients. Toxins (Basel) 2019, 11, 431. [Google Scholar] [CrossRef] [Green Version]
- Diaz-Ricart, M.; Torramade-Moix, S.; Pascual, G.; Palomo, M.; Moreno-Castano, A.B.; Martinez-Sanchez, J.; Vera, M.; Cases, A.; Escolar, G. Endothelial Damage, Inflammation and Immunity in Chronic Kidney Disease. Toxins (Basel) 2020, 12, 361. [Google Scholar] [CrossRef] [PubMed]
- Komada, T.; Muruve, D.A. The role of inflammasomes in kidney disease. Nat. Rev. Nephrol. 2019, 15, 501–520. [Google Scholar] [CrossRef] [PubMed]
- Broz, P.; Dixit, V.M. Inflammasomes: Mechanism of assembly, regulation and signalling. Nat. Rev. Immunol. 2016, 16, 407–420. [Google Scholar] [CrossRef] [PubMed]
- Hung, S.C.; Kuo, K.L.; Peng, C.H.; Wu, C.H.; Lien, Y.C.; Wang, Y.C.; Tarng, D.C. Volume overload correlates with cardiovascular risk factors in patients with chronic kidney disease. Kidney Int. 2014, 85, 703–709. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Dekker, M.J.E.; van der Sande, F.M.; van den Berghe, F.; Leunissen, K.M.L.; Kooman, J.P. Fluid Overload and Inflammation Axis. Blood Purif. 2018, 45, 159–165. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Ulrich, C.; Wilke, A.; Schleicher, N.; Girndt, M.; Fiedler, R. Hypervolemia-Induced Immune Disturbances Do Not Involve IL-1ss but IL-6 and IL-10 Activation in Haemodialysis Patients. Toxins (Basel) 2020, 12, 159. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Maynard, C.L.; Elson, C.O.; Hatton, R.D.; Weaver, C.T. Reciprocal interactions of the intestinal microbiota and immune system. Nature 2012, 489, 231–241. [Google Scholar] [CrossRef] [Green Version]
- Glorieux, G.; Gryp, T.; Perna, A. Gut-Derived Metabolites and Their Role in Immune Dysfunction in Chronic Kidney Disease. Toxins (Basel) 2020, 12, 245. [Google Scholar] [CrossRef] [Green Version]
- Espi, M.; Koppe, L.; Fouque, D.; Thaunat, O. Chronic Kidney Disease-Associated Immune Dysfunctions: Impact of Protein-Bound Uremic Retention Solutes on Immune Cells. Toxins (Basel) 2020, 12, 300. [Google Scholar] [CrossRef]
- Cohen, G.; Haag-Weber, M.; Mai, B.; Deicher, R.; Horl, W.H. Effect of immunoglobulin light chains from hemodialysis and continuous ambulatory peritoneal dialysis patients on polymorphonuclear leukocyte functions. J. Am. Soc. Nephrol. 1995, 6, 1592–1599. [Google Scholar]
- Kirsch, A.H.; Lyko, R.; Nilsson, L.G.; Beck, W.; Amdahl, M.; Lechner, P.; Schneider, A.; Wanner, C.; Rosenkranz, A.R.; Krieter, D.H. Performance of hemodialysis with novel medium cut-off dialyzers. Nephrol. Dial. Transplant. 2017, 32, 165–172. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Allawati, H.; Dallas, L.; Nair, S.; Palmer, J.; Thaikandy, S.; Hutchison, C. A Pharmacokinetic Study Comparing the Clearance of Vancomycin during Haemodialysis Using Medium Cut-Off Membrane (Theranova) and High-Flux Membranes (Revaclear). Toxins (Basel) 2020, 12, 317. [Google Scholar] [CrossRef] [PubMed]
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Cohen, G.; Vanholder, R. Special Issue: Immune Dysfunction in Uremia. Toxins 2021, 13, 70. https://doi.org/10.3390/toxins13010070
Cohen G, Vanholder R. Special Issue: Immune Dysfunction in Uremia. Toxins. 2021; 13(1):70. https://doi.org/10.3390/toxins13010070
Chicago/Turabian StyleCohen, Gerald, and Raymond Vanholder. 2021. "Special Issue: Immune Dysfunction in Uremia" Toxins 13, no. 1: 70. https://doi.org/10.3390/toxins13010070