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Centipede Venom Peptides Acting on Ion Channels

by 1,2,3,4,*, 1,2,3,4 and 1,2,3,*
1
School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China
2
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China
3
Innovation Center for Marine Drug Screening & Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China
4
Marine Biomedical Research Institute of Qingdao, Qingdao 266071, China
*
Authors to whom correspondence should be addressed.
Toxins 2020, 12(4), 230; https://doi.org/10.3390/toxins12040230
Received: 1 March 2020 / Revised: 30 March 2020 / Accepted: 1 April 2020 / Published: 5 April 2020
(This article belongs to the Section Animal Venoms)
Centipedes are among the oldest venomous arthropods that use their venom to subdue the prey. The major components of centipede venom are a variety of low-molecular-weight peptide toxins that have evolved to target voltage-gated ion channels to interfere with the central system of prey and produce pain or paralysis for efficient hunting. Peptide toxins usually contain several intramolecular disulfide bonds, which confer chemical, thermal and biological stability. In addition, centipede peptides generally have novel structures and high potency and specificity and therefore hold great promise both as diagnostic tools and in the treatment of human disease. Here, we review the centipede peptide toxins with reported effects on ion channels, including Nav, Kv, Cav and the nonselective cation channel polymodal transient receptor potential vanilloid 1 (TRPV1). View Full-Text
Keywords: animal toxin; ion channel; centipede venom; drug discovery; peptide drug animal toxin; ion channel; centipede venom; drug discovery; peptide drug
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MDPI and ACS Style

Chu, Y.; Qiu, P.; Yu, R. Centipede Venom Peptides Acting on Ion Channels. Toxins 2020, 12, 230. https://doi.org/10.3390/toxins12040230

AMA Style

Chu Y, Qiu P, Yu R. Centipede Venom Peptides Acting on Ion Channels. Toxins. 2020; 12(4):230. https://doi.org/10.3390/toxins12040230

Chicago/Turabian Style

Chu, YanYan, PeiJu Qiu, and RiLei Yu. 2020. "Centipede Venom Peptides Acting on Ion Channels" Toxins 12, no. 4: 230. https://doi.org/10.3390/toxins12040230

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