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Article

A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication

1
Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
2
Mapp Biopharmaceutical, Inc. 6160 Lusk Blvd, San Diego, CA 92121, USA
*
Author to whom correspondence should be addressed.
Toxins 2020, 12(4), 215; https://doi.org/10.3390/toxins12040215
Received: 20 February 2020 / Revised: 24 March 2020 / Accepted: 26 March 2020 / Published: 29 March 2020
(This article belongs to the Special Issue Inhibitors and Countermeasures against Bacterial and Plant Toxins)
PB10 IgG1, a monoclonal antibody (MAb) directed against an immunodominant epitope on the enzymatic subunit (RTA) of ricin toxin (RT), has been shown to passively protect mice and non-human primates from an aerosolized lethal-dose RT challenge. However, it was recently demonstrated that the therapeutic efficacy of PB10 IgG1 is significantly improved when co-administered with a second MAb, SylH3, targeting RT’s binding subunit (RTB). Here we report that the PB10/SylH3 cocktail is also superior to PB10 alone when used as a pre-exposure prophylactic (PrEP) in a mouse model of intranasal RT challenge. The benefit of the PB10/SylH3 cocktail prompted us to engineer a humanized IgG1 version of SylH3 (huSylH3). The huPB10/huSylH3 cocktail proved highly efficacious in the mouse model, thereby opening the door to future testing in non-human primates. View Full-Text
Keywords: toxin; lung; antibody; biodefense; prophylactic toxin; lung; antibody; biodefense; prophylactic
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MDPI and ACS Style

Rong, Y.; Pauly, M.; Guthals, A.; Pham, H.; Ehrbar, D.; Zeitlin, L.; Mantis, N.J. A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication. Toxins 2020, 12, 215. https://doi.org/10.3390/toxins12040215

AMA Style

Rong Y, Pauly M, Guthals A, Pham H, Ehrbar D, Zeitlin L, Mantis NJ. A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication. Toxins. 2020; 12(4):215. https://doi.org/10.3390/toxins12040215

Chicago/Turabian Style

Rong, Yinghui; Pauly, Michael; Guthals, Adrian; Pham, Henry; Ehrbar, Dylan; Zeitlin, Larry; Mantis, Nicholas J. 2020. "A Humanized Monoclonal Antibody Cocktail to Prevent Pulmonary Ricin Intoxication" Toxins 12, no. 4: 215. https://doi.org/10.3390/toxins12040215

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