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Article

Impact of Chronic Levels of Naturally Multi-Contaminated Feed with Fusarium Mycotoxins on Broiler Chickens and Evaluation of the Mitigation Properties of Different Titers of Yeast Cell Wall Extract

1
Alltech, Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356, USA
2
Southern Poultry Research, Inc., Athens, GA 30607, USA
*
Author to whom correspondence should be addressed.
Toxins 2020, 12(10), 636; https://doi.org/10.3390/toxins12100636
Received: 7 July 2020 / Revised: 20 August 2020 / Accepted: 21 September 2020 / Published: 1 October 2020
The chronic intake of naturally multi-mycotoxin contaminated feed by broilers with or without titers of Yeast Cell Wall Extract (YCWE, a.k.a Mycosorb A+®), was investigated. Day-old male Cobb chicks (1600 birds, 64 pens, 25 birds/pen) were randomly allocated to diets of control (CON); diet containing mycotoxins (MT); CON + 0.2% YCWE; MT + 0.025% YCWE; MT + 0.05% YCWE; MT + 0.1% YCWE; MT + 0.2% YCWE; and MT + 0.4% YCWE. Growth performance, blood biochemical parameters and gut health were recorded over 42 days. Compared with CON, MT had reduced body weight (BW) and increased feed conversion ratio (FCR) on days 35 and 42 with increased duodenal crypt depth and fewer goblet cells. Furthermore, European Poultry Production Efficiency (EPEF) was reduced for MT versus CON. Feeding MT + 0.2% YCWE improved BW, lowered FCR, reduced crypt depth, increased goblet cell count and improved EPEF. Considering titration of YCWE (0 to 0.4%) during mycotoxin challenge, a cubic effect was observed for FCR with NC + 0.2% YCWE having the lowest FCR. These findings suggest that chronic consumption of multiple Fusarium mycotoxins present in common field concentrations can negatively impact broiler performance and gut health while inclusion of YCWE, particularly 0.2%, could be effective in counteracting mycotoxins. View Full-Text
Keywords: broiler; gastrointestinal; mycotoxins; mycotoxin mitigation; yeast cell wall extract broiler; gastrointestinal; mycotoxins; mycotoxin mitigation; yeast cell wall extract
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MDPI and ACS Style

Weaver, A.C.; King, W.D.; Verax, M.; Fox, U.; Kudupoje, M.B.; Mathis, G.; Lumpkins, B.; Yiannikouris, A. Impact of Chronic Levels of Naturally Multi-Contaminated Feed with Fusarium Mycotoxins on Broiler Chickens and Evaluation of the Mitigation Properties of Different Titers of Yeast Cell Wall Extract. Toxins 2020, 12, 636. https://doi.org/10.3390/toxins12100636

AMA Style

Weaver AC, King WD, Verax M, Fox U, Kudupoje MB, Mathis G, Lumpkins B, Yiannikouris A. Impact of Chronic Levels of Naturally Multi-Contaminated Feed with Fusarium Mycotoxins on Broiler Chickens and Evaluation of the Mitigation Properties of Different Titers of Yeast Cell Wall Extract. Toxins. 2020; 12(10):636. https://doi.org/10.3390/toxins12100636

Chicago/Turabian Style

Weaver, Alexandra C., W. D. King, Morgan Verax, Ursula Fox, Manoj B. Kudupoje, Greg Mathis, Brett Lumpkins, and Alexandros Yiannikouris. 2020. "Impact of Chronic Levels of Naturally Multi-Contaminated Feed with Fusarium Mycotoxins on Broiler Chickens and Evaluation of the Mitigation Properties of Different Titers of Yeast Cell Wall Extract" Toxins 12, no. 10: 636. https://doi.org/10.3390/toxins12100636

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