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Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

Laboratory of Dermatology and Immunodeficiencies (LIM-56), Department of Dermatology, University of Sao Paulo Medical School, Sao Paulo-SP 01246-903, Brazil
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These authors shared the mentorship, critical revision and supervision of this review.
Toxins 2019, 11(6), 321; https://doi.org/10.3390/toxins11060321
Received: 8 May 2019 / Revised: 28 May 2019 / Accepted: 30 May 2019 / Published: 5 June 2019
(This article belongs to the Special Issue Staphylococcus aureus Toxins)
Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30–100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease. View Full-Text
Keywords: Staphylococcus aureus; enterotoxins; atopic dermatitis; innate immunity; adaptive immunity; microbiome Staphylococcus aureus; enterotoxins; atopic dermatitis; innate immunity; adaptive immunity; microbiome
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Seiti Yamada Yoshikawa, F.; Feitosa de Lima, J.; Notomi Sato, M.; Álefe Leuzzi Ramos, Y.; Aoki, V.; Leao Orfali, R. Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis. Toxins 2019, 11, 321.

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