Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population
AbstractProtein-bound uremic toxins (PBUTs) play a role in the multisystem disease that children on hemodialysis (HD) are facing, but little is known about their levels and protein binding (%PB). In this study, we evaluated the levels and %PB of six PBUTs cross-sectionally in a large pediatric HD cohort (n = 170) by comparing these with healthy and non-dialysis chronic kidney disease (CKD) stage 4–5 (n = 24) children. In parallel β2-microglobulin (β2M) and uric acid (UA) were evaluated. We then explored the impact of age and residual kidney function on uremic toxin levels and %PB using analysis of covariance and Spearman correlation coefficients (rs). We found higher levels of β2M, p-cresyl glucuronide (pCG), hippuric acid (HA), indole acetic acid (IAA), and indoxyl sulfate (IxS) in the HD compared to the CKD4–5 group. In the HD group, a positive correlation between age and pCG, HA, IxS, and pCS levels was shown. Residual urine volume was negatively correlated with levels of β2M, pCG, HA, IAA, IxS, and CMPF (rs −0.2 to −0.5). In addition, we found overall lower %PB of PBUTs in HD versus the CKD4–5 group, and showed an age-dependent increase in %PB of IAA, IxS, and pCS. Furhtermore, residual kidney function was overall positively correlated with %PB of PBUTs. In conclusion, residual kidney function and age contribute to PBUT levels and %PB in the pediatric HD population. View Full-Text
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Snauwaert, E.; Holvoet, E.; Van Biesen, W.; Raes, A.; Glorieux, G.; Vande Walle, J.; Roels, S.; Vanholder, R.; Askiti, V.; Azukaitis, K.; Bayazit, A.; Canpolat, N.; Fischbach, M.; Godefroid, N.; Krid, S.; Litwin, M.; Obrycki, L.; Paglialonga, F.; Ranchin, B.; Samaille, C.; Schaefer, F.; Schmitt, C.P.; Spasojevic, B.; Stefanidis, C.J.; Van Dyck, M.; Van Hoeck, K.; Collard, L.; Eloot, S.; Shroff, R. Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population. Toxins 2019, 11, 235.
Snauwaert E, Holvoet E, Van Biesen W, Raes A, Glorieux G, Vande Walle J, Roels S, Vanholder R, Askiti V, Azukaitis K, Bayazit A, Canpolat N, Fischbach M, Godefroid N, Krid S, Litwin M, Obrycki L, Paglialonga F, Ranchin B, Samaille C, Schaefer F, Schmitt CP, Spasojevic B, Stefanidis CJ, Van Dyck M, Van Hoeck K, Collard L, Eloot S, Shroff R. Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population. Toxins. 2019; 11(4):235.Chicago/Turabian Style
Snauwaert, Evelien; Holvoet, Els; Van Biesen, Wim; Raes, Ann; Glorieux, Griet; Vande Walle, Johan; Roels, Sanne; Vanholder, Raymond; Askiti, Varvara; Azukaitis, Karolis; Bayazit, Aysun; Canpolat, Nur; Fischbach, Michel; Godefroid, Nathalie; Krid, Saoussen; Litwin, Mieczyslaw; Obrycki, Lukasz; Paglialonga, Fabio; Ranchin, Bruno; Samaille, Charlotte; Schaefer, Franz; Schmitt, Claus P.; Spasojevic, Brankica; Stefanidis, Constantinos J.; Van Dyck, Maria; Van Hoeck, Koen; Collard, Laure; Eloot, Sunny; Shroff, Rukshana. 2019. "Uremic Toxin Concentrations are Related to Residual Kidney Function in the Pediatric Hemodialysis Population." Toxins 11, no. 4: 235.
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