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Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor

Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, Korea
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Author to whom correspondence should be addressed.
Toxins 2018, 10(4), 146; https://doi.org/10.3390/toxins10040146
Received: 8 February 2018 / Revised: 25 March 2018 / Accepted: 31 March 2018 / Published: 2 April 2018
(This article belongs to the Special Issue Venom and Toxin as Targeted Therapy)
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by highly pruritic, erythematous, and eczematous skin plaques. We previously reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In this study, we showed that PLA2 treatment inhibited epidermal thickness, serum immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration in the ear of an AD model induced by DFE and DNCB. In contrast, these effects were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB in the ear. These data suggest that bvPLA2 alleviates atopic skin inflammation via interaction with CD206. View Full-Text
Keywords: atopic dermatitis (AD); house dust mite extract (DFE); 2,4-dinitrochlorobenzene (DNCB); bee venom phospholipase A2 (bvPLA2); skin inflammation; CD206; mannose receptor atopic dermatitis (AD); house dust mite extract (DFE); 2,4-dinitrochlorobenzene (DNCB); bee venom phospholipase A2 (bvPLA2); skin inflammation; CD206; mannose receptor
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Shin, D.; Choi, W.; Bae, H. Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor. Toxins 2018, 10, 146.

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