Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor
Abstract
:1. Introduction
2. Results
2.1. bvPLA2 Treatment Alleviated DFE/DNCB-Induced Ear Thickness and AD-Like Symptoms
2.2. bvPLA2 Reduced Serum IgE in DFE/DNCB-Treated Mice
2.3. bvPLA2 Abrogated AD-Related Th1 and Th2 Cytokine Production via CD206
2.4. bvPLA2 Is Associated with Treg Induction through the CD206 Receptor
2.5. bvPLA2 Decreased DFE/DNCB-Induced Epidermal and Dermal Thickness and Infiltration of Inflammatory Cells Depending on CD206
2.6. bvPLA2 Blocked Mast Cell Infiltration in DFE/DNCB-Induced AD via CD206
3. Discussion
4. Materials and Methods
4.1. Animal
4.2. Reagents
4.3. Experimental Protocol
4.4. Measurement of Serum Immunoglobulin E (IgE)
4.5. Assessment of Th1 and Th2 Cytokine Levels in Mouse Ear
4.6. Western Blot Assay
4.7. Histological Analysis
4.8. Statistical Analyses
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Shin, D.; Choi, W.; Bae, H. Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor. Toxins 2018, 10, 146. https://doi.org/10.3390/toxins10040146
Shin D, Choi W, Bae H. Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor. Toxins. 2018; 10(4):146. https://doi.org/10.3390/toxins10040146
Chicago/Turabian StyleShin, Dasom, Won Choi, and Hyunsu Bae. 2018. "Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor" Toxins 10, no. 4: 146. https://doi.org/10.3390/toxins10040146