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The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study

Department of Nutrition and Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
School of Health Sciences, Universiti Sains Malaysia, Gelugor 11800, Malaysia
Center for Southeast Asian Studies, Kyoto University, Kyoto 606-8501, Japan
Author to whom correspondence should be addressed.
Nutrients 2017, 9(7), 716;
Received: 31 May 2017 / Revised: 26 June 2017 / Accepted: 30 June 2017 / Published: 7 July 2017
(This article belongs to the Special Issue Selected Papers from APNNO Biennial Conference 2016)
Background: Obesity has been associated with leptin resistance and this might be caused by genetic factors. The aim of this study was to investigate the gene-lifestyle interaction between −866G/A UCP2 (uncoupling protein 2) gene polymorphism, dietary intake and leptin in a population based study. Methods: This is a cross sectional study conducted in adults living at urban area of Yogyakarta, Indonesia. Data of adiposity, lifestyle, triglyceride, high density lipoprotein (HDL) cholesterol, leptin and UCP2 gene polymorphism were obtained in 380 men and female adults. Results: UCP2 gene polymorphism was not significantly associated with adiposity, leptin, triglyceride, HDL cholesterol, dietary intake and physical activity (all p > 0.05). Leptin was lower in overweight subjects with AA + GA genotypes than those with GG genotype counterparts (p = 0.029). In subjects with AA + GA genotypes there was a negative correlation between leptin concentration (r = −0.324; p < 0.0001) and total energy intake and this correlation was not seen in GG genotype (r = −0.111; p = 0.188). Conclusions: In summary, we showed how genetic variation in −866G/A UCP2 affected individual response to leptin production. AA + GA genotype had a better leptin sensitivity shown by its response in dietary intake and body mass index (BMI) and this explained the protective effect of A allele to obesity. View Full-Text
Keywords: UCP2; leptin; dietary intake; adiposity; obesity UCP2; leptin; dietary intake; adiposity; obesity
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Luglio, H.F.; Sulistyoningrum, D.C.; Huriyati, E.; Lee, Y.Y.; Wan Muda, W.A.M. The Gene-Lifestyle Interaction on Leptin Sensitivity and Lipid Metabolism in Adults: A Population Based Study. Nutrients 2017, 9, 716.

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