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Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress

by Mustapha Umar Imam 1,†, Shenshen Zhang 1,†, Jifei Ma 1, Hao Wang 1,2 and Fudi Wang 1,2,*
Department of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Department of Nutrition, Nutrition Discovery Innovation Center, School of Public Health, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou 310058, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2017, 9(7), 671;
Received: 4 June 2017 / Revised: 20 June 2017 / Accepted: 22 June 2017 / Published: 28 June 2017
(This article belongs to the Special Issue Antioxidants in Health and Disease)
Oxidative stress is a common denominator in the pathogenesis of many chronic diseases. Therefore, antioxidants are often used to protect cells and tissues and reverse oxidative damage. It is well known that iron metabolism underlies the dynamic interplay between oxidative stress and antioxidants in many pathophysiological processes. Both iron deficiency and iron overload can affect redox state, and these conditions can be restored to physiological conditions using iron supplementation and iron chelation, respectively. Similarly, the addition of antioxidants to these treatment regimens has been suggested as a viable therapeutic approach for attenuating tissue damage induced by oxidative stress. Notably, many bioactive plant-derived compounds have been shown to regulate both iron metabolism and redox state, possibly through interactive mechanisms. This review summarizes our current understanding of these mechanisms and discusses compelling preclinical evidence that bioactive plant-derived compounds can be both safe and effective for managing both iron deficiency and iron overload conditions. View Full-Text
Keywords: iron homeostasis; iron overload; antioxidants; plant extracts; oxidative stress; ferroptosis iron homeostasis; iron overload; antioxidants; plant extracts; oxidative stress; ferroptosis
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Imam, M.U.; Zhang, S.; Ma, J.; Wang, H.; Wang, F. Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress. Nutrients 2017, 9, 671.

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