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The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention

Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0738, USA
Department of Family Medicine and Public Health, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0901, USA
Author to whom correspondence should be addressed.
Nutrients 2017, 9(6), 552;
Received: 16 March 2017 / Revised: 9 May 2017 / Accepted: 22 May 2017 / Published: 27 May 2017
(This article belongs to the Special Issue Nutrigenetics)
We recently reported that interleukin-6 (IL-6), an inflammatory marker associated with breast pathology and the development of breast cancer, decreases with diet intervention and weight loss in both insulin-sensitive and insulin-resistant obese women. Here, we tested whether an individual’s genotype at an IL6 SNP, rs1800795, which has previously been associated with circulating IL-6 levels, contributes to changes in IL-6 levels or modifies the effect of diet composition on IL-6 in these women. We genotyped rs1800795 in overweight/obese women (N = 242) who were randomly assigned to a lower fat (20% energy), higher carbohydrate (65% energy) diet; a lower carbohydrate (45% energy), higher fat (35% energy) diet; or a walnut-rich (18% energy), higher fat (35% energy), lower carbohydrate (45% energy) diet in a 1-year weight loss intervention study of obesity-related biomarkers for breast cancer incidence and mortality. Plasma IL-6 levels were measured at baseline, 6 and 12 months. At baseline, individuals with a CC genotype had significantly lower IL-6 levels than individuals with either a GC or GG genotype (p < 0.03; 2.72 pg/mL vs. 2.04 pg/mL), but this result was not significant when body mass index (BMI) was accounted for; the CC genotype group had lower BMI (p = 0.03; 32.5 kg/m2 vs. 33.6 kg/m2). We did not observe a 2-way interaction of time*rs1800795 genotype or diet*rs1800795 genotype. Our findings provide evidence that rs1800795 is associated with IL-6 levels, but do not support a differential interaction effect of rs1800795 and diet composition or time on changes in circulating IL-6 levels. Diet intervention and weight loss are an important strategy for reducing plasma IL-6, a risk factor of breast cancer in women, regardless of their rs1800795 genotype. View Full-Text
Keywords: IL-6; rs1800795; diet intervention; BMI; walnut IL-6; rs1800795; diet intervention; BMI; walnut
MDPI and ACS Style

Rana, B.K.; Flatt, S.W.; Health, D.D.; Pakiz, B.; Quintana, E.L.; Natarajan, L.; Rock, C.L. The IL6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention. Nutrients 2017, 9, 552.

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