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Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79079-900, MS, Brazil
Department of Pharmacology, Biomedical Science Institute, University of São Paulo, São Paulo 05508900, SP, Brazil
Post-Graduate Program in Biotechnology, Catholic University Dom Bosco, Campo Grande 79117-900, MS, Brazil
Author to whom correspondence should be addressed.
Nutrients 2017, 9(6), 540;
Received: 27 December 2016 / Revised: 23 March 2017 / Accepted: 26 April 2017 / Published: 25 May 2017
Cultural and economic shifts in the early 19th century led to the rapid development of companies that made good profits from technologically-produced commodities. In this way, some habits changed in society, such as the overconsumption of processed and micronutrient-poor foods and devices that gave rise to a sedentary lifestyle. These factors influenced host-microbiome interactions which, in turn, mediated the etiopathogenesis of “new-era” disorders and diseases, which are closely related, such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, hypertension, and inflammatory bowel disease, which are characterized by chronic dysregulation of metabolic and immune processes. These pathological conditions require novel and effective therapeutic approaches. Morinda citrifolia (noni) is well known as a traditional healing plant due to its medicinal properties. Thus, many studies have been conducted to understand its bioactive compounds and their mechanisms of action. However, in obesity and obesity-related metabolic (dysfunction) syndrome, other studies are necessary to better elucidate noni’s mechanisms of action, mainly due to the complexity of the pathophysiology of obesity and its metabolic dysfunction. In this review, we summarize not only the clinical effects, but also important cell signaling pathways in in vivo and in vitro assays of potent bioactive compounds present in the noni plant which have been reported in studies of obesity and obesity-associated metabolic dysfunction. View Full-Text
Keywords: Morinda citrifolia L.; obesity; obesity-related metabolic dysfunction; health Morinda citrifolia L.; obesity; obesity-related metabolic dysfunction; health
MDPI and ACS Style

Inada, A.C.; Figueiredo, P.S.; Santos-Eichler, R.A.; Freitas, K.D.C.; Hiane, P.A.; Castro, A.P.; Guimarães, R.D.C.A. Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction. Nutrients 2017, 9, 540.

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