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Nutrients 2017, 9(5), 446;

Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression

Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, VialeTaramelli 12, 27100 Pavia, Italy
KOLINPHARMA S.p.A., Lainate, Corso Europa 5, 20020 Lainate (MI), Italy
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19395-5487, Tehran 19395-5487, Iran
Grup de Nutrició Comunitària i Estrès Oxidatiu and CIBEROBN (Physiopathology of Obesity and Nutrition), Universitat de les Illes Balears, Palma de E-07122 Mallorca, Spain
Department of Physiology, Faculty of Biological Sciences, Shahid Behshti University, P.O. Box 19615-1178, Tehran 19615-1178, Iran
Department of Biology, Faculty of Basic Sciences, University of Mazandaran, 47416-95447 Babolsar, Iran
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Australia
CHeBA NPI, Euroa Centre, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia
Authors to whom correspondence should be addressed.
Received: 26 February 2017 / Revised: 2 April 2017 / Accepted: 24 April 2017 / Published: 29 April 2017
(This article belongs to the Special Issue Antioxidants in Health and Disease)
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Green GABA (GGABA) and Oolong GABA (OGABA) teas are relatively new varieties of tea, whose chemical composition and functional properties are largely under-studied, despite their promising health capacities. Post stroke depression (PSD) is a complication of stroke with high clinical relevance, yielding increasing mortality and morbidity rates, and a lower response to common therapies and rehabilitation. Methods: Two chemically characterized commercial samples of GGABA and OGABA were investigated for effects on mood following oral administration using a mouse model of PSD, through common validated tests including the Despair Swimming Test and Tail Suspension Test. Moreover, the antioxidant activity of GGABA and OGABA was evaluated by determining the levels of lipid peroxidation products and the activity of antioxidant enzymes in the mouse brain in vivo. Results: GGABA and OGABA attenuated depressed mood by influencing behavioral parameters linked to depression. GGABA was more active than OGABA in this study, and this effect may be likely due to a higher content of polyphenolic substances and amino acids in GGABA compared to OGABA. GGABA also exerted a greater antioxidant activity. Conclusions: Our data suggests that GABA tea is a promising candidate that can be used as an adjuvant in the management of PSD. View Full-Text
Keywords: GABA green tea; GABA oolong tea; post-stroke depression; antioxidant activity GABA green tea; GABA oolong tea; post-stroke depression; antioxidant activity

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Daglia, M.; Di Lorenzo, A.; Nabavi, S.F.; Sureda, A.; Khanjani, S.; Moghaddam, A.H.; Braidy, N.; Nabavi, S.M. Improvement of Antioxidant Defences and Mood Status by Oral GABA Tea Administration in a Mouse Model of Post-Stroke Depression. Nutrients 2017, 9, 446.

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