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Open AccessArticle

Maternal Prebiotic Ingestion Increased the Number of Fecal Bifidobacteria in Pregnant Women but Not in Their Neonates Aged One Month

1
Food Science Research Laboratories, R&D Division, Meiji Co., Ltd., 540 Naruda, Odawaara Kanagawa 250-0862, Japan
2
Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
3
Department of Pediatrics, National Shimoshizu Hospital, Chiba 284-0003, Japan
4
Masuda Maternity Clinic, Chiba 289-2144, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(3), 196; https://doi.org/10.3390/nu9030196
Received: 19 October 2016 / Revised: 17 February 2017 / Accepted: 21 February 2017 / Published: 26 February 2017
Fructooligosaccharides (FOS) can selectively stimulate the growth of bifidobacteria. Here, we investigated the effect of maternal FOS ingestion on maternal and neonatal gut bifidobacteria. In a randomized, double-blind, placebo-controlled study, we administered 8 g/day of FOS or sucrose to 84 women from the 26th week of gestation to one month after delivery. The bifidobacteria count was detected using quantitative PCR in maternal (26 and 36 weeks of gestation) and neonatal (one month after delivery) stools. Maternal stool frequency was recorded from 24 to 36 weeks of gestation. The number of fecal Bifidobacterium spp. and Bifidobacterium longum in the FOS group was significantly higher than that in the placebo group at 36 weeks of gestation (2.7 × 1010/g vs. 1.1 × 1010/g and 2.3 × 1010/g vs. 9.7 × 109/g). In their neonates, these numbers did not differ between the groups. Also, stool frequency in the FOS group was slightly higher than that in the placebo group two weeks after the intervention (1.0 vs. 0.8 times/day), suggesting a potential constipation alleviation effect. In conclusion, the maternal FOS ingestion showed a bifidogenic effect in pregnant women but not in their neonates. View Full-Text
Keywords: fructooligosaccharides; bifidobacteria; feces; infancy; pregnancy; prebiotic; constipation; stool frequency fructooligosaccharides; bifidobacteria; feces; infancy; pregnancy; prebiotic; constipation; stool frequency
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Jinno, S.; Toshimitsu, T.; Nakamura, Y.; Kubota, T.; Igoshi, Y.; Ozawa, N.; Suzuki, S.; Nakano, T.; Morita, Y.; Arima, T.; Yamaide, F.; Kohno, Y.; Masuda, K.; Shimojo, N. Maternal Prebiotic Ingestion Increased the Number of Fecal Bifidobacteria in Pregnant Women but Not in Their Neonates Aged One Month. Nutrients 2017, 9, 196.

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