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Nutrients 2017, 9(3), 183;

Pancreatic Exocrine Insufficiency in Pancreatic Cancer

Center for Digestive Diseases, Karolinska University Hospital, Stockholm SE-141 86, Sweden
Author to whom correspondence should be addressed.
Received: 21 December 2016 / Revised: 27 January 2017 / Accepted: 17 February 2017 / Published: 23 February 2017
(This article belongs to the Special Issue Nutrition and Pancreatic Health)
PDF [877 KB, uploaded 23 February 2017]


Abstract: Cancer patients experience weight loss for a variety of reasons, commencing with the tumor’s metabolism (Warburg effect) and proceeding via cachexia to loss of appetite. In pancreatic cancer, several other factors are involved, including a loss of appetite with a particular aversion to meat and the incapacity of the pancreatic gland to function normally when a tumor is present in the pancreatic head. Pancreatic exocrine insufficiency is characterized by a deficiency of the enzymes secreted from the pancreas due to the obstructive tumor, resulting in maldigestion. This, in turn, contributes to malnutrition, specifically a lack of fat-soluble vitamins, antioxidants, and other micronutrients. Patients with pancreatic cancer and pancreatic exocrine insufficiency have, overall, an extremely poor prognosis with regard to surgical outcome and overall survival. Therefore, it is crucial to be aware of the mechanisms involved in the disease, to be able to diagnose pancreatic exocrine insufficiency early on, and to treat malnutrition appropriately, for example, with pancreatic enzymes. View Full-Text
Keywords: pancreatic exocrine insufficiency; pancreatic cancer; pancreatic surgery; malnutrition; vitamin pancreatic exocrine insufficiency; pancreatic cancer; pancreatic surgery; malnutrition; vitamin

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Vujasinovic, M.; Valente, R.; Del Chiaro, M.; Permert, J.; Löhr, J.-M. Pancreatic Exocrine Insufficiency in Pancreatic Cancer. Nutrients 2017, 9, 183.

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