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Open AccessFeature PaperReview

Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Office of Dietary Supplements, National Institutes of Health, 6100 Executive Blvd, 3B01, Bethesda, MD 20892, USA
Author to whom correspondence should be addressed.
Nutrients 2017, 9(12), 1327;
Received: 12 October 2017 / Revised: 26 November 2017 / Accepted: 28 November 2017 / Published: 6 December 2017
(This article belongs to the Special Issue Dietary Supplements)
Iron is particularly important in pregnancy and infancy to meet the high demands for hematopoiesis, growth and development. Much attention has been given to conditions of iron deficiency (ID) and iron deficient anemia (IDA) because of the high global prevalence estimated in these vulnerable life stages. Emerging and preliminary evidence demonstrates, however, a U-shaped risk at both low and high iron status for birth and infant adverse health outcomes including growth, preterm birth, gestational diabetes, gastrointestinal health, and neurodegenerative diseases during aging. Such evidence raises questions about the effects of high iron intakes through supplementation or food fortification during pregnancy and infancy in iron-replete individuals. This review examines the emerging as well as the current understanding of iron needs and homeostasis during pregnancy and infancy, uncertainties in ascertaining iron status in these populations, and issues surrounding U-shaped risk curves in iron-replete pregnant women and infants. Implications for research and policy are discussed relative to screening and supplementation in these vulnerable populations, especially in developed countries in which the majority of these populations are likely iron-replete. View Full-Text
Keywords: iron supplementation; iron-replete; pregnancy; infancy iron supplementation; iron-replete; pregnancy; infancy
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Brannon, P.M.; Taylor, C.L. Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy. Nutrients 2017, 9, 1327.

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