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A Correlation Study of DHA Intake Estimated by a FFQ and Concentrations in Plasma and Erythrocytes in Mid- and Late Pregnancy

1
Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center, 38 Xueyuan Rd., Beijing 100191, China
2
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Rd., Beijing 100191, China
3
Department of Pediatrics, School of Medicine, New York University, 227 East 30th Street, Room 735, New York, NY 10016, USA
4
Wyeth Nutrition Science Center, 582 Wuzhong Rd., Shanghai 201103, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2017, 9(11), 1256; https://doi.org/10.3390/nu9111256
Received: 21 August 2017 / Revised: 13 November 2017 / Accepted: 14 November 2017 / Published: 16 November 2017
Adequate docosahexaenoic acid (DHA) is essential for the optimal growth and development of the fetus. Maternal DHA content fluctuates during pregnancy. The correlation of DHA content with dietary intake might be varied over the course of pregnancy. We aimed to compare the dietary DHA intake, estimated by a DHA-specific semiquantitative food frequency questionnaire (FFQ) against its blood content, among mid- and late-term pregnant women. A total of 804 Chinese pregnant women completed the tailored FFQ and provided fasting venous blood samples. Dietary DHA intake (mg/day) in the previous month was calculated from the FFQ using Chinese Food Composition Table. DHA concentrations (weight percent of total fatty acids) in plasma and erythrocytes were measured by capillary gas chromatography. Spearman correlation coefficients (rs) between DHA intake and its relative concentrations were calculated. After adjustment for maternal age, pre-pregnancy body mass index, stage of pregnancy, parity, education level, ethnicity, and annual family income per capita, the correlation coefficients of DHA intake with its concentrations in plasma and erythrocytes were 0.35 and 0.33, respectively (p < 0.001). The correlations were relatively stronger among women in late pregnancy (rs = 0.44 in plasma and 0.39 in erythrocytes) than those in mid-pregnancy (rs = 0.25 and 0.26). The significant correlations were consistently observed in subgroups stratified by regions, except for erythrocytes in women living in a coastland area. Multiple regression analyses also indicated significant positive linear correlations between DHA intake and its plasma or erythrocytes concentrations (p < 0.001). In conclusion, dietary DHA intake, estimated by the FFQ, was positively correlated with its concentrations in plasma and erythrocytes in Chinese pregnant women, especially for women in late pregnancy, with the exception of the erythrocytes of those living in a coastland area. View Full-Text
Keywords: docosahexaenoic acid; pregnant women; food frequency questionnaire; plasma; erythrocytes docosahexaenoic acid; pregnant women; food frequency questionnaire; plasma; erythrocytes
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Zhou, Y.-B.; Li, H.-T.; Trasande, L.; Wang, L.-L.; Zhang, Y.-L.; Si, K.-Y.; Bai, M.-X.; Liu, J.-M. A Correlation Study of DHA Intake Estimated by a FFQ and Concentrations in Plasma and Erythrocytes in Mid- and Late Pregnancy. Nutrients 2017, 9, 1256.

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