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Nutrients 2017, 9(10), 1112;

The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 5C9, Canada
Division of Digestive Care & Endoscopy, Department of Community Health and Epidemiology, Dalhousie University, Truro, NS B2N 5E3, Canada
College of Medicine, University of Manitoba, Winnipeg, MB R3T 2N2, Canada
College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia
Pure North S’Energy Foundation, Calgary, AB T2R 0C5, Canada
Author to whom correspondence should be addressed.
Received: 22 May 2017 / Revised: 28 September 2017 / Accepted: 6 October 2017 / Published: 12 October 2017
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We determined the association between vitamin D status as 25hydroxyvitamin D [25(OH)D] and disease activity in a cohort of 201 Crohn’s Disease (CD) patients in Saskatoon, Canada over three years. The association between high-sensitivity C-reactive protein (hs-CRP) and 25(OH)D and several disease predictors were evaluated by the generalized estimating equation (GEE) over three time-point measurements. A GEE binary logistic regression test was used to evaluate the association between vitamin D status and the Harvey-Bradshaw Index (HBI). The deficient vitamin D group (≤29 nmol/L) had significantly higher mean hs-CRP levels compared with the three other categories of vitamin D status (p < 0.05). CRP was significantly lower in all of the other groups compared with the vitamin D-deficient group, which had Coef. = 12.8 units lower (95% CI −19.8, −5.8), Coef. 7.85 units (95% CI −14.9, −0.7), Coef. 9.87 units (95% CI −17.6, −2.0) for the vitamin D insufficient, adequate, and optimal groups, respectively. The vitamin D status was associated with the HBI active disease category. However, the difference in the odds ratio compared with the reference category of deficient vitamin D category was only significant in the insufficient category (odds ratio = 3.45, p = 0.03, 95% CI 1.0, 10.8). Vitamin D status was inversely associated with indicators of disease activity in Crohn’s disease, particularly with the objective measures of inflammation. View Full-Text
Keywords: Crohn’s disease; vitamin D; disease activity; inflammatory bowel diseases Crohn’s disease; vitamin D; disease activity; inflammatory bowel diseases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Alrefai, D.; Jones, J.; El-Matary, W.; Whiting, S.J.; Aljebreen, A.; Mirhosseini, N.; Vatanparast, H. The Association of Vitamin D Status with Disease Activity in a Cohort of Crohn’s Disease Patients in Canada. Nutrients 2017, 9, 1112.

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