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Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials

1
Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
2
Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing 100101, China
3
Biochemistry and Nutrition Research Centre, School of Medicine, Mashhad University of Medical Science, Mashhad 42536, Iran
4
Division of Medical Education, Brighton and Sussex Medical School, Rm 342, Mayfield House, University of Brighton, Brighton BN1 9PH, UK
5
College of Pharmacy and Nutrition, University of Saskatchewan, Health Sciences E-Wing, 104 Clinic Place, Saskatoon, SK S7N 2Z4, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2017, 9(1), 20; https://doi.org/10.3390/nu9010020
Received: 20 July 2016 / Revised: 15 October 2016 / Accepted: 15 December 2016 / Published: 3 January 2017
We conducted this systematic review and meta-analysis of prospective studies to determine the effect of probiotic administration on serum C-reactive protein (CRP) concentrations. We searched PubMed-Medline, Web of Science, the Cochrane, and Google Scholar databases (until May 2016) to identify prospective studies evaluating the impact of probiotic administration on CRP. We used a random effects models and generic inverse variance methods to synthesize quantitative data, followed by a leave-one-out method for sensitivity analysis. The systematic review registration number was: CRD42016039457. From a total of 425 entries identified via searches, 20 studies were included in the final analysis. The meta-analysis indicated a significant reduction in serum CRP following probiotic administration with a weighted mean difference (WMD) of −1.35 mg/L, (95% confidence interval (CI) −2.15 to −0.55, I2 65.1%). The WMDs for interleukin 10 (IL10) was −1.65 pg/dL, (95% CI −3.45 to 0.14, I2 3.1%), and −0.45 pg/mL, (95% CI −1.38 to 0.48, I2 10.2%) for tumor necrosis factor alpha (TNF-α). These findings were robust in sensitivity analyses. This meta-analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α. View Full-Text
Keywords: meta-analysis; probiotic; C-reactive protein meta-analysis; probiotic; C-reactive protein
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MDPI and ACS Style

Mazidi, M.; Rezaie, P.; Ferns, G.A.; Vatanparast, H. Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials. Nutrients 2017, 9, 20. https://doi.org/10.3390/nu9010020

AMA Style

Mazidi M, Rezaie P, Ferns GA, Vatanparast H. Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials. Nutrients. 2017; 9(1):20. https://doi.org/10.3390/nu9010020

Chicago/Turabian Style

Mazidi, Mohsen; Rezaie, Peyman; Ferns, Gordon A.; Vatanparast, Hassan. 2017. "Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials" Nutrients 9, no. 1: 20. https://doi.org/10.3390/nu9010020

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