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Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials

Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing 100101, China
Biochemistry and Nutrition Research Centre, School of Medicine, Mashhad University of Medical Science, Mashhad 42536, Iran
Division of Medical Education, Brighton and Sussex Medical School, Rm 342, Mayfield House, University of Brighton, Brighton BN1 9PH, UK
College of Pharmacy and Nutrition, University of Saskatchewan, Health Sciences E-Wing, 104 Clinic Place, Saskatoon, SK S7N 2Z4, Canada
Author to whom correspondence should be addressed.
Nutrients 2017, 9(1), 20;
Received: 20 July 2016 / Revised: 15 October 2016 / Accepted: 15 December 2016 / Published: 3 January 2017
We conducted this systematic review and meta-analysis of prospective studies to determine the effect of probiotic administration on serum C-reactive protein (CRP) concentrations. We searched PubMed-Medline, Web of Science, the Cochrane, and Google Scholar databases (until May 2016) to identify prospective studies evaluating the impact of probiotic administration on CRP. We used a random effects models and generic inverse variance methods to synthesize quantitative data, followed by a leave-one-out method for sensitivity analysis. The systematic review registration number was: CRD42016039457. From a total of 425 entries identified via searches, 20 studies were included in the final analysis. The meta-analysis indicated a significant reduction in serum CRP following probiotic administration with a weighted mean difference (WMD) of −1.35 mg/L, (95% confidence interval (CI) −2.15 to −0.55, I2 65.1%). The WMDs for interleukin 10 (IL10) was −1.65 pg/dL, (95% CI −3.45 to 0.14, I2 3.1%), and −0.45 pg/mL, (95% CI −1.38 to 0.48, I2 10.2%) for tumor necrosis factor alpha (TNF-α). These findings were robust in sensitivity analyses. This meta-analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-α. View Full-Text
Keywords: meta-analysis; probiotic; C-reactive protein meta-analysis; probiotic; C-reactive protein
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Mazidi, M.; Rezaie, P.; Ferns, G.A.; Vatanparast, H. Impact of Probiotic Administration on Serum C-Reactive Protein Concentrations: Systematic Review and Meta-Analysis of Randomized Control Trials. Nutrients 2017, 9, 20.

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