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Open AccessArticle

Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue

1
Center for Food and Nutritional Genomics Research, Kyungpook National University, 1370 San-Kyuk Dong Puk-Ku, Daegu 41566, Korea
2
Department of Food Science and Nutrition, Kyungpook National University, 1370 San-Kyuk Dong Puk-Ku, Daegu 702-701, Korea
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Department of Food and Nutrition, Sunchon National University, Suncheon 540-950, Korea
4
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, 1370 San-Kyuk Dong Puk-Ku, Daegu 702-701, Korea
5
Department of Food Science and Nutrition, University of Ulsan, Ulsan 44610, Korea
6
Department of Food and Nutrition, Sookmyung Women’s University, Seoul 04310, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(9), 532; https://doi.org/10.3390/nu8090532
Received: 30 June 2016 / Revised: 19 August 2016 / Accepted: 25 August 2016 / Published: 30 August 2016
The Platycodon grandiflorus root, a Korean medicinal food, is well known to have beneficial effects on obesity and diabetes. In this study, we demonstrated the metabolic effects of P. grandiflorus root ethanol extract (PGE), which is rich in platycodins, on diet-induced obesity. C57BL/6J mice (four-week-old males) were fed a normal diet (16.58% of kilocalories from fat), high-fat diet (HFD, 60% of kilocalories from fat), and HFD supplemented with 5% (w/w) PGE. In the HFD-fed mice, PGE markedly suppressed the body weight gain and white fat mass to normal control level, with simultaneous increase in the expression of thermogenic genes (such as SIRT1, PPARα, PGC1α, and UCP1), that accompanied changes in fatty acid oxidation (FAO) and energy expenditure. In addition, PGE improved insulin sensitivity through activation of the PPARγ expression, which upregulates adiponectin while decreasing leptin gene expression in adipocytes. Furthermore, PGE improved hepatic steatosis by suppressing hepatic lipogenesis while increasing expression of FAO-associated genes such as PGC1α. PGE normalized body fat and body weight, which is likely associated with the increased energy expenditure and thermogenic gene expression. PGE can protect from HFD-induced insulin resistance, and hepatic steatosis by controlling lipid and glucose metabolism. View Full-Text
Keywords: Platycodon grandiflorus root; obesity; free fatty acid oxidation; energy expenditure; thermogenesis Platycodon grandiflorus root; obesity; free fatty acid oxidation; energy expenditure; thermogenesis
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Kim, Y.J.; Choi, J.-Y.; Ryu, R.; Lee, J.; Cho, S.-J.; Kwon, E.-Y.; Lee, M.-K.; Liu, K.-H.; Rina, Y.; Sung, M.-K.; Choi, M.-S. Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue. Nutrients 2016, 8, 532.

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