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Open AccessArticle

Barley Sprouts Extract Attenuates Alcoholic Fatty Liver Injury in Mice by Reducing Inflammatory Response

1
College of Pharmacy, Yonsei University, Incheon 21983, Korea
2
Department of Bio Health Science, College of Natural Science, Changwon National University, Changwon 51140, Korea
3
College of Pharmacy, Pusan National University, Busan 46241, Korea
4
Crop Foundation Division, National Institute of Crop Science, Rural Development Administration, Wanju-Gun, Jeollabuk-do 54875, Korea
5
Life Science Research Institute, Novarex Co., Ltd, Ochang, Cheongwon, Cheongju 28126, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(7), 440; https://doi.org/10.3390/nu8070440
Received: 8 May 2016 / Revised: 2 July 2016 / Accepted: 15 July 2016 / Published: 21 July 2016
(This article belongs to the Special Issue Health-Promoting Components of Fruits and Vegetables in Human Health)
It has been reported that barley leaves possess beneficial properties such as antioxidant, hypolipidemic, antidepressant, and antidiabetic. Interestingly, barley sprouts contain a high content of saponarin, which showed both anti-inflammatory and antioxidant activities. In this study, we evaluated the effect of barley sprouts on alcohol-induced liver injury mediated by inflammation and oxidative stress. Raw barley sprouts were extracted, and quantitative and qualitative analyses of its components were performed. The mice were fed a liquid alcohol diet with or without barley sprouts for four weeks. Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells were used to study the effect of barley sprouts on inflammation. Alcohol intake for four weeks caused liver injury, evidenced by an increase in serum alanine aminotransferase and aspartate aminotransferase activities and tumor necrosis factor (TNF)-α levels. The accumulation of lipid in the liver was also significantly induced, whereas the glutathione (GSH) level was reduced. Moreover, the inflammation-related gene expression was dramatically increased. All these alcohol-induced changes were effectively prevented by barley sprouts treatment. In particular, pretreatment with barley sprouts significantly blocked inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 expression in LPS-stimulated RAW 264.7. This study suggests that the protective effect of barley sprouts against alcohol-induced liver injury is potentially attributable to its inhibition of the inflammatory response induced by alcohol. View Full-Text
Keywords: barley sprouts; alcohol-induced liver injury; glutathione; TNF-α; inflammation barley sprouts; alcohol-induced liver injury; glutathione; TNF-α; inflammation
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Lee, Y.-H.; Kim, J.-H.; Kim, S.H.; Oh, J.Y.; Seo, W.D.; Kim, K.-M.; Jung, J.-C.; Jung, Y.-S. Barley Sprouts Extract Attenuates Alcoholic Fatty Liver Injury in Mice by Reducing Inflammatory Response. Nutrients 2016, 8, 440.

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