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Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density

1,2,*,†, 2,3,†, 4,†, 3, 5,* and 1,*
The First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, 277 Yanta West Road, Xi’an 710061, Shaanxi, China
School of Public Health, Xi’an Jiaotong University Health Science Center, 76 Yanta West Road, Xi’an 710061, Shaanxi, China
The 3201 Hospital, Xi’an Jiao tong University College of Medicine, 783 Tianhan Road, Hanzhong 723000, Shaanxi, China
The Ninth Hospital of Xi’an, Xi’an Jiaotong University College of Medicine, 151 East of South Second Ring Road, Xi’an 710054, Shaanxi, China
National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Beijing 100050, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(7), 426;
Received: 19 June 2016 / Revised: 2 July 2016 / Accepted: 6 July 2016 / Published: 12 July 2016
PDF [1255 KB, uploaded 12 July 2016]


The purpose of this study was to evaluate the effects of lutein, zeaxanthin and meso-zeaxanthin on macular pigment optical density (MPOD) in randomized controlled trials (RCTs) among patients with age-related macular degeneration (AMD) and healthy subjects. Medline, Embase, Web of Science and Cochrane Library databases was searched through May 2016. Meta-analysis was conducted to obtain adjusted weighted mean differences (WMD) for intervention-versus-placebo group about the change of MPOD between baseline and terminal point. Pearson correlation analysis was used to determine the relationship between the changes in MPOD and blood xanthophyll carotenoids or baseline MPOD levels. Twenty RCTs involving 938 AMD patients and 826 healthy subjects were identified. Xanthophyll carotenoids supplementation was associated with significant increase in MPOD in AMD patients (WMD, 0.07; 95% CI, 0.03 to 0.11) and healthy subjects (WMD, 0.09; 95% CI, 0.05 to 0.14). Stratified analysis showed a greater increase in MPOD among trials supplemented and combined with meso-zeaxanthin. Additionally, the changes in MPOD were related with baseline MPOD levels (rAMD = −0.43, p = 0.06; rhealthy subjects = −0.71, p < 0.001) and blood xanthophyll carotenoids concentration (rAMD = 0.40, p = 0.07; rhealthy subjects = 0.33, p = 0.05). This meta-analysis revealed that lutein, zeaxanthin and meso-zeaxanthin supplementation improved MPOD both in AMD patients and healthy subjects with a dose-response relationship. View Full-Text
Keywords: lutein; zeaxanthin; meso-zeaxanthin; macular pigment optical density lutein; zeaxanthin; meso-zeaxanthin; macular pigment optical density

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Ma, L.; Liu, R.; Du, J.H.; Liu, T.; Wu, S.S.; Liu, X.H. Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density. Nutrients 2016, 8, 426.

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