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Nutrients
Volume 8
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10.3390/nu8060346
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Article

Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers

by
Sean Austin
1,*,
Carlos A. De Castro
1,
Thierry Bénet
1,
Yangfeng Hou
2,
Henan Sun
2,
Sagar K. Thakkar
1,
Gerard Vinyes-Pares
2,
Yumei Zhang
3 and
Peiyu Wang
4
1
Nestlé Research Centre, Vers-Chez-Les-Blanc, Lausanne 1000, Switzerland
2
Nestlé Research Center Beijing, Beijing 100095, China
3
Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing 100191, China
4
Department of Social Medicine and Health Education, School of Public Health, Peking University Health Science Center, Beijing 100191, China
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(6), 346; https://doi.org/10.3390/nu8060346
Submission received: 5 April 2016 / Revised: 20 May 2016 / Accepted: 31 May 2016 / Published: 8 June 2016
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Abstract

Breastfed infants tend to be less prone to infections and may have improved cognitive benefits compared to formula-fed infants. Human milk oligosaccharides (HMO) are the third most abundant component of human milk, but are absent from formulae. They may be partially responsible for the benefits of breastfeeding. In this cross-sectional observational study, the HMO composition of milk from Chinese mothers was studied to determine the impact of stage of lactation, mode of delivery and geographical location. The content of 10 HMO was measured by HPLC in 446 milk samples from mothers living in three different cities in China. Around 21% of the samples contained levels of 2′-fucosyllactose (2′-FL) below the limit of quantification, which is similar to the frequency of fucosyltransferase-2 non-secretors in other populations, but 2′-FL was detected in all samples. Levels of most of the HMO studied decreased during the course of lactation, but the level of 3-fucosyllactose increased. Levels of 2′-FL and 3-fucosyllactose seem to be strongly correlated, suggesting some sort of mechanism for co-regulation. Levels of 6′-sialyllactose were higher than those of 3′-sialyllactose at early stages of lactation, but beyond 2–4 months, 3′-sialyllactose was predominant. Neither mode of delivery nor geographical location had any impact on HMO composition.
Keywords: human milk oligosaccharides; lactation; HPLC; sialyllactose; fucosyllactose; lacto-N-tetraose; lacto-N-neotetraose; lacto-N-fucosylpentaose human milk oligosaccharides; lactation; HPLC; sialyllactose; fucosyllactose; lacto-N-tetraose; lacto-N-neotetraose; lacto-N-fucosylpentaose
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MDPI and ACS Style

Austin, S.; De Castro, C.A.; Bénet, T.; Hou, Y.; Sun, H.; Thakkar, S.K.; Vinyes-Pares, G.; Zhang, Y.; Wang, P. Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers. Nutrients 2016, 8, 346. https://doi.org/10.3390/nu8060346

AMA Style

Austin S, De Castro CA, Bénet T, Hou Y, Sun H, Thakkar SK, Vinyes-Pares G, Zhang Y, Wang P. Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers. Nutrients. 2016; 8(6):346. https://doi.org/10.3390/nu8060346

Chicago/Turabian Style

Austin, Sean, Carlos A. De Castro, Thierry Bénet, Yangfeng Hou, Henan Sun, Sagar K. Thakkar, Gerard Vinyes-Pares, Yumei Zhang, and Peiyu Wang. 2016. "Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers" Nutrients 8, no. 6: 346. https://doi.org/10.3390/nu8060346

APA Style

Austin, S., De Castro, C. A., Bénet, T., Hou, Y., Sun, H., Thakkar, S. K., Vinyes-Pares, G., Zhang, Y., & Wang, P. (2016). Temporal Change of the Content of 10 Oligosaccharides in the Milk of Chinese Urban Mothers. Nutrients, 8(6), 346. https://doi.org/10.3390/nu8060346

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