Next Article in Journal
Salvianolic Acid B Inhibits Aβ Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells
Next Article in Special Issue
Biomarkers of Aging: From Function to Molecular Biology
Previous Article in Journal
Does the Australasian “Health Star Rating” Front of Pack Nutritional Label System Work?
Previous Article in Special Issue
Cardiovascular, Metabolic Effects and Dietary Composition of Ad-Libitum Paleolithic vs. Australian Guide to Healthy Eating Diets: A 4-Week Randomised Trial
Open AccessArticle

The Relationship between Vitamin D Status and Allergic Diseases in New Zealand Preschool Children

School of Food and Nutrition, Massey University, Auckland 0632, New Zealand
Department of Paediatrics, University of Auckland and General Paediatrics, Auckland 1010, New Zealand
Starship Children’s Hospital, Aucklan 1023, New Zealand
CSIRO Food and Nutrition, Adelaide 5000, Australia
Institute of Natural and Mathematical Sciences, Massey University, Auckland 0632, New Zealand
Department of Human Nutrition, University of Otago, Dunedin 9016, New Zealand
Queensland Brain Institute, University of Queensland, Brisbane 4072, Australia
Queensland Centre for Mental Health Research, Brisbane 4072, Australia
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Author to whom correspondence should be addressed.
Nutrients 2016, 8(6), 326;
Received: 23 March 2016 / Revised: 17 May 2016 / Accepted: 20 May 2016 / Published: 1 June 2016
Recent research on vitamin D in young children has expanded from bone development to exploring immunomodulatory effects. Our aim was to investigate the relationship of vitamin D status and allergic diseases in preschool-aged children in New Zealand. Dried capillary blood spots were collected from 1329 children during late-winter to early-spring for 25(OH)D measurement by LC-MS/MS. Caregivers completed a questionnaire about their child’s recent medical history. Analysis was by multivariable logistic regression. Mean 25(OH)D concentration was 52(SD19) nmol/L, with 7% of children <25 nmol/L and 49% <50 nmol/L. Children with 25(OH)D concentrations ≥75 nmol/L (n = 29) had a two-fold increased risk for parent-report of doctor-diagnosed food allergy compared to children with 25(OH)D 50–74.9 nmol/L (OR = 2.21, 1.33–3.68, p = 0.002). No associations were present between 25(OH)D concentration and presence of parent-reported eczema, allergic rhinoconjunctivitis or atopic asthma. Vitamin D deficiency was not associated with several allergic diseases in these New Zealand preschool children. In contrast, high 25(OH)D concentrations were associated with a two-fold increased risk of parental-report food allergy. This increase supports further research into the association between vitamin D status and allergic disease in preschool children. View Full-Text
Keywords: vitamin D; children; allergic disease; New Zealand vitamin D; children; allergic disease; New Zealand
MDPI and ACS Style

Cairncross, C.; Grant, C.; Stonehouse, W.; Conlon, C.; McDonald, B.; Houghton, L.; Eyles, D.; Camargo, C.A., Jr.; Coad, J.; Von Hurst, P. The Relationship between Vitamin D Status and Allergic Diseases in New Zealand Preschool Children. Nutrients 2016, 8, 326.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop