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Open AccessArticle

The Relationship between Vitamin D Status and Allergic Diseases in New Zealand Preschool Children

1
School of Food and Nutrition, Massey University, Auckland 0632, New Zealand
2
Department of Paediatrics, University of Auckland and General Paediatrics, Auckland 1010, New Zealand
3
Starship Children’s Hospital, Aucklan 1023, New Zealand
4
CSIRO Food and Nutrition, Adelaide 5000, Australia
5
Institute of Natural and Mathematical Sciences, Massey University, Auckland 0632, New Zealand
6
Department of Human Nutrition, University of Otago, Dunedin 9016, New Zealand
7
Queensland Brain Institute, University of Queensland, Brisbane 4072, Australia
8
Queensland Centre for Mental Health Research, Brisbane 4072, Australia
9
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
*
Author to whom correspondence should be addressed.
Nutrients 2016, 8(6), 326; https://doi.org/10.3390/nu8060326
Received: 23 March 2016 / Revised: 17 May 2016 / Accepted: 20 May 2016 / Published: 1 June 2016
Recent research on vitamin D in young children has expanded from bone development to exploring immunomodulatory effects. Our aim was to investigate the relationship of vitamin D status and allergic diseases in preschool-aged children in New Zealand. Dried capillary blood spots were collected from 1329 children during late-winter to early-spring for 25(OH)D measurement by LC-MS/MS. Caregivers completed a questionnaire about their child’s recent medical history. Analysis was by multivariable logistic regression. Mean 25(OH)D concentration was 52(SD19) nmol/L, with 7% of children <25 nmol/L and 49% <50 nmol/L. Children with 25(OH)D concentrations ≥75 nmol/L (n = 29) had a two-fold increased risk for parent-report of doctor-diagnosed food allergy compared to children with 25(OH)D 50–74.9 nmol/L (OR = 2.21, 1.33–3.68, p = 0.002). No associations were present between 25(OH)D concentration and presence of parent-reported eczema, allergic rhinoconjunctivitis or atopic asthma. Vitamin D deficiency was not associated with several allergic diseases in these New Zealand preschool children. In contrast, high 25(OH)D concentrations were associated with a two-fold increased risk of parental-report food allergy. This increase supports further research into the association between vitamin D status and allergic disease in preschool children. View Full-Text
Keywords: vitamin D; children; allergic disease; New Zealand vitamin D; children; allergic disease; New Zealand
MDPI and ACS Style

Cairncross, C.; Grant, C.; Stonehouse, W.; Conlon, C.; McDonald, B.; Houghton, L.; Eyles, D.; Camargo, C.A., Jr.; Coad, J.; Von Hurst, P. The Relationship between Vitamin D Status and Allergic Diseases in New Zealand Preschool Children. Nutrients 2016, 8, 326.

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