Next Article in Journal
Vitamin B12 Status among Pregnant Women in the UK and Its Association with Obesity and Gestational Diabetes
Next Article in Special Issue
Potential of Lactobacillus plantarum CCFM639 in Protecting against Aluminum Toxicity Mediated by Intestinal Barrier Function and Oxidative Stress
Previous Article in Journal
Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study
Previous Article in Special Issue
Sodium Butyrate Reduces Colitogenic Immunoglobulin A-Coated Bacteria and Modifies the Composition of Microbiota in IL-10 Deficient Mice
Article

Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk

1
Digestive Department, Hospital of Jerez de la Frontera, Cádiz E-11403, Spain
2
Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, Granada E-18071, Spain
3
Instituto de Investigación Biosanitaria (IBS), University of Granada, Granada E-18012, Spain
4
Hepatology Department, Granada Hospital Complex, Granada E-18012, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2016, 8(12), 780; https://doi.org/10.3390/nu8120780
Received: 26 October 2016 / Revised: 9 November 2016 / Accepted: 25 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue Nutrition and Diet in IBD)
The incidence of inflammatory bowel disease (IBD) and associated oxidative stress is increasing. The antioxidant mineral selenium (Se) was measured in serum samples from 106 IBD patients (53 with ulcerative colitis (UC) and 53 with Crohn’s disease (CD)) and from 30 healthy controls. Serum Se concentrations were significantly lower in UC and CD patients than in healthy controls (p < 0.001) and significantly lower in CD patients than in UC patients (p = 0.006). Se concentrations in patients were significantly influenced by sex, body mass index (BMI), the inflammatory biomarker α-1-antitrypsin, surgery, medical treatment, the severity, extent, and form of the disease and the length of time since onset (p < 0.05). Se concentrations in IBD patients were positively and linearly correlated with nutritional (protein, albumin, prealbumin, cholinesterase and total cholesterol) and iron status-related (hemoglobin, Fe and hematocrit) parameters (p < 0.05). A greater impairment of serum Se and cardiovascular status was observed in CD than in UC patients. An adequate nutritional Se status is important in IBD patients to minimize the cardiovascular risk associated with increased inflammation biomarkers, especially in undernourished CD patients, and is also related to an improved nutritional and body iron status. View Full-Text
Keywords: ulcerative colitis; Crohn’s disease; selenium; influencing factors; nutritional and biochemical markers ulcerative colitis; Crohn’s disease; selenium; influencing factors; nutritional and biochemical markers
Show Figures

Graphical abstract

MDPI and ACS Style

Castro Aguilar-Tablada, T.; Navarro-Alarcón, M.; Quesada Granados, J.; Samaniego Sánchez, C.; Rufián-Henares, J.Á.; Nogueras-Lopez, F. Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk. Nutrients 2016, 8, 780. https://doi.org/10.3390/nu8120780

AMA Style

Castro Aguilar-Tablada T, Navarro-Alarcón M, Quesada Granados J, Samaniego Sánchez C, Rufián-Henares JÁ, Nogueras-Lopez F. Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk. Nutrients. 2016; 8(12):780. https://doi.org/10.3390/nu8120780

Chicago/Turabian Style

Castro Aguilar-Tablada, Teresa; Navarro-Alarcón, Miguel; Quesada Granados, Javier; Samaniego Sánchez, Cristina; Rufián-Henares, José Á.; Nogueras-Lopez, Flor. 2016. "Ulcerative Colitis and Crohn’s Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk" Nutrients 8, no. 12: 780. https://doi.org/10.3390/nu8120780

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop