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Open AccessArticle

Does Human Milk Modulate Body Composition in Late Preterm Infants at Term-Corrected Age?

Fondazione I.R.C.C.S. Ca Granda Ospedale Maggiore Policlinico, Neonatal Intensive Care Unit, Department of Clinical Science and Community Health, University of Milan, Via Commenda 12, 20122 Milano, Italy
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Epidemiology Unit, Via San Barnaba 8, 20122 Milan, Italy
Author to whom correspondence should be addressed.
Nutrients 2016, 8(10), 664;
Received: 26 July 2016 / Revised: 4 October 2016 / Accepted: 18 October 2016 / Published: 23 October 2016
(This article belongs to the Special Issue Nutrients in Infancy)
(1) Background: Late preterm infants account for the majority of preterm births and are at risk of altered body composition. Because body composition modulates later health outcomes and human milk is recommended as the normal method for infant feeding, we sought to investigate whether human milk feeding in early life can modulate body composition development in late preterm infants; (2) Methods: Neonatal, anthropometric and feeding data of 284 late preterm infants were collected. Body composition was evaluated at term-corrected age by air displacement plethysmography. The effect of human milk feeding on fat-free mass and fat mass content was evaluated using multiple linear regression analysis; (3) Results: Human milk was fed to 68% of the infants. According to multiple regression analysis, being fed any human milk at discharge and at term-corrected and being fed exclusively human milk at term-corrected age were positively associated with fat-free mass content(β = −47.9, 95% confidence interval (CI) = −95.7; −0.18; p = 0.049; β = −89.6, 95% CI = −131.5; −47.7; p < 0.0001; β = −104.1, 95% CI = −151.4; −56.7, p < 0.0001); (4) Conclusion: Human milk feeding appears to be associated with fat-free mass deposition in late preterm infants. Healthcare professionals should direct efforts toward promoting and supporting breastfeeding in these vulnerable infants. View Full-Text
Keywords: human milk; late preterm infants; body composition human milk; late preterm infants; body composition
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Giannì, M.L.; Consonni, D.; Liotto, N.; Roggero, P.; Morlacchi, L.; Piemontese, P.; Menis, C.; Mosca, F. Does Human Milk Modulate Body Composition in Late Preterm Infants at Term-Corrected Age? Nutrients 2016, 8, 664.

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