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Association of Parental Environmental Exposures and Supplementation Intake with Risk of Nonsyndromic Orofacial Clefts: A Case-Control Study in Heilongjiang Province, China

1
Department of Oral Maxillofacial Surgery, The First Affiliated Hospital, Harbin Medical University, 122 Youzheng Street, Nangang District, Harbin 150000, China
2
Department of Stomatology, Harbin Children's Hospital, 57 Youyi Road, Daoli District, Harbin 150000, China
3
Department of Medical Administration, The Second Affiliated Hospital, Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin 150000, China
4
Department of Stomatology, The Fourth Affiliated Hospital, Harbin Medical University, 37 Yiyuan Street, Nangang District, Harbin 150000, China
*
Author to whom correspondence should be addressed.
Nutrients 2015, 7(9), 7172-7184; https://doi.org/10.3390/nu7095328
Received: 17 May 2015 / Revised: 11 August 2015 / Accepted: 20 August 2015 / Published: 27 August 2015
The aim of present study was to check the possible association of potential parental environmental exposures and maternal supplementation intake with the risk of nonsyndromic orofacial clefting (NSOC). A retrospective study comprised 499 cases and 480 controls was conducted in Heilongjiang Province. Chi-square analysis and unconditional multiple logistic regression were used in the study. The results showed that maternal history of fever and the common cold without fever (ORCL/P = 3.11 and 5.56, 95%CI: 1.67–5.82 and 2.96–10.47, ORCPO = 3.31 and 8.23, 95%CI: 1.58–6.94 and 4.08–16.95), paternal smoking and alcohol consumption (ORCL/P = 2.15 and 5.04, 95%CI: 1.37–3.38 and 3.00–8.46, ORCPO = 1.82 and 4.40, 95%CI: 1.06–3.13 and 2.50–7.74), maternal exposure to organic solvents, heavy metals, or pesticides (ORCL/P = 6.07, 5.67 and 5.97, 95%CI: 1.49–24.76, 1.34–24.09 and 2.10–16.98, ORCPO = 10.65, 7.28 and 3.48, 95%CI: 2.54–44.67, 1.41–37.63 and 1.06–11.46) and multivitamin use during the preconception period (ORCL/P = 0.06, 95%CI: 0.02–0.23, ORCPO = 0.06, 95%CI: 0.01–0.30) were associated with cleft lip or without cleft palate (CL/P) and cleft palate only (CPO). Maternal history of skin disease and negative life events (ORCL/P = 12.07 and 1.67, 95%CI: 1.81–80.05 and 1.95–2.67) were associated with CL/P. Some potential parental hazardous exposures during the periconception period and maternal use of multivitamins during the preconception period were associated with risk of NSOC. View Full-Text
Keywords: nonsyndromic orofacial clefts; environmental exposures; passive smoking; toxic occupational exposure; multivitamin use; folic acid nonsyndromic orofacial clefts; environmental exposures; passive smoking; toxic occupational exposure; multivitamin use; folic acid
MDPI and ACS Style

Hao, Y.; Tian, S.; Jiao, X.; Mi, N.; Zhang, B.; Song, T.; An, L.; Zheng, X.; Zhuang, D. Association of Parental Environmental Exposures and Supplementation Intake with Risk of Nonsyndromic Orofacial Clefts: A Case-Control Study in Heilongjiang Province, China. Nutrients 2015, 7, 7172-7184.

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