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Effectiveness of Dietary Allergen Exclusion Therapy on Eosinophilic Colitis in Chinese Infants and Young Children ≤ 3 Years of Age

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Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China
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Department of Pathology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China
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Division of Gastroenterology, Children's Mercy Hospitals and Clinics, Kansas City 64108, MO, USA
*
Authors to whom correspondence should be addressed.
Nutrients 2015, 7(3), 1817-1827; https://doi.org/10.3390/nu7031817
Received: 20 November 2014 / Revised: 6 February 2015 / Accepted: 16 February 2015 / Published: 11 March 2015
Eosinophilic colitis is a well recognized clinical entity mainly associated with food allergies. Empiric treatment options include dietary allergen exclusion (extensively hydrolyzed protein formula and elimination diet), anti-allergy medications (antihistamines and leukotriene receptor antagonists) and corticosteroids. We evaluated the effectiveness of dietary antigen exclusion on clinical remission of eosinophilic colitis in infants and young children. We retrospectively reviewed charts of all infants and children ≤3 years of age who were diagnosed with eosinophilic colitis (defined as mucosal eosinophilia ≥20 hpf1) from 1 January 2011 to 31 December 2013 at a tertiary children’s hospital in China. Forty-nine children were identified with eosinophilic colitis. Elemental formula, simple elimination diet or combination therapy resulted in clinical improvement in 75%, 88.2% and 80% of patients, respectively. In conclusion, eosinophilic colitis in infants and children ≤3 years of age responded well to dietary allergen exclusion. View Full-Text
Keywords: eosinophilic colitis; infants; children; dietary exclusion eosinophilic colitis; infants; children; dietary exclusion
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Yang, M.; Geng, L.; Chen, P.; Wang, F.; Xu, Z.; Liang, C.; Li, H.; Fang, T.; Friesen, C.A.; Gong, S.; Li, D. Effectiveness of Dietary Allergen Exclusion Therapy on Eosinophilic Colitis in Chinese Infants and Young Children ≤ 3 Years of Age. Nutrients 2015, 7, 1817-1827.

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