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Open AccessArticle

The Ratio of Dietary Branched-Chain Amino Acids is Associated with a Lower Prevalence of Obesity in Young Northern Chinese Adults: An Internet-Based Cross-Sectional Study

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Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China
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College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China
*
Authors to whom correspondence should be addressed.
Nutrients 2015, 7(11), 9573-9589; https://doi.org/10.3390/nu7115486
Received: 9 October 2015 / Revised: 3 November 2015 / Accepted: 11 November 2015 / Published: 18 November 2015
This study aims to examine the association between the ratio of dietary branched chain amino acids (BCAA) and risk of obesity among young northern Chinese adults. A total of 948 randomly recruited participants were asked to finish our internet-based dietary questionnaire for the Chinese (IDQC). Associations between dietary BCAA ratio and prevalence of overweight/obesity and abdominal obesity were analyzed. Furthermore, 90 subjects were randomly selected to explore the possible mechanism. Dietary BCAA ratio in obese participants was significantly lower than non-obese participants. We found negative correlations between the ratio of dietary BCAA and body mass index (BMI) (r = −0.197, p < 0.001) or waist circumference (r = −0.187, p < 0.001). Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartiles of dietary BCAA ratio for overweight/obesity were 0.508 (0.265–0.972) and 0.389 (0.193–0.783), respectively (all p < 0.05). After stratification by gender, the significance still existed in the 3rd and 4th quartile in males and the 4th quartile in females. For abdominal obesity, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartile of dietary BCAA ratio were 0.351 (0.145–0.845) and 0.376 (0.161–0.876), respectively (all p < 0.05). This significance was stronger in males. Further studies indicated that dietary BCAA ratio was inversely associated with 2-h postprandial glucose (2 h-PG) and status of inflammation. In conclusion, a higher ratio of dietary BCAA is inversely associated with prevalence of obesity, postprandial glucose and status of inflammation in young northern Chinese adults. View Full-Text
Keywords: dietary BCAA; overweight/obesity; abdominal obesity; 2 h-PG; inflammation dietary BCAA; overweight/obesity; abdominal obesity; 2 h-PG; inflammation
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Li, Y.-C.; Li, Y.; Liu, L.-Y.; Chen, Y.; Zi, T.-Q.; Du, S.-S.; Jiang, Y.-S.; Feng, R.-N.; Sun, C.-H. The Ratio of Dietary Branched-Chain Amino Acids is Associated with a Lower Prevalence of Obesity in Young Northern Chinese Adults: An Internet-Based Cross-Sectional Study. Nutrients 2015, 7, 9573-9589.

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