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The Spectrum of Differences between Childhood and Adulthood Celiac Disease

Rachele Ciccocioppo, Center for the Study and Cure of Celiac Disease, Clinica Medica I, Department of Internal Medicine, IRCCS Policlinico San Matteo Foundation, University of Pavia, 19–27100 Pavia, Italy
International Clinical Research Center, St. Anne’s University Hospital and Masaryk University, 65691 Brno, Czech Republic
Faculty of Military Health Sciences, University of Defence, Trebešská 1575-500 01 Hradec Kralove, Czech Republic
Department of Geology and Pedology, Faculty of Forestry and Wood Technology, Mendel University in Brno, 61300 Brno, Czech Republic
Gastroenterology Unit, Hospital Universitario Central de Asturias, 33000 Oviedo, Spain
Author to whom correspondence should be addressed.
Nutrients 2015, 7(10), 8733-8751;
Received: 1 August 2015 / Revised: 6 October 2015 / Accepted: 12 October 2015 / Published: 22 October 2015
(This article belongs to the Special Issue Gluten Related Disorders: People Shall not Live on Bread Alone)
An old saying states that ‘’children are not little adults” and this certainly holds true for celiac disease, as there are many peculiar aspects regarding its epidemiology, diagnosis, clinical presentations, associated diseases, and response to treatment in pediatric compared to adult populations, to such an extent that it merits a description of its own. In fact, contrary to the past when it was thought that celiac disease was a disorder predominantly affecting childhood and characterized by a malabsorption syndrome, nowadays it is well recognized that it affects also adult and elderly people with an impressive variability of clinical presentation. In general, the clinical guidelines for diagnosis recommend starting with specific serologic testing in all suspected subjects, including those suffering from extraintestinal related conditions, and performing upper endoscopy with appropriate biopsy sampling of duodenal mucosa in case of positivity. The latter may be omitted in young patients showing high titers of anti-transglutaminase antibodies. The subsequent management of a celiac patient differs substantially depending on the age at diagnosis and should be based on the important consideration that this is a lifelong condition. View Full-Text
Keywords: adulthood; associated diseases; childhood; complications. adulthood; associated diseases; childhood; complications.
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MDPI and ACS Style

Ciccocioppo, R.; Kruzliak, P.; Cangemi, G.C.; Pohanka, M.; Betti, E.; Lauret, E.; Rodrigo, L. The Spectrum of Differences between Childhood and Adulthood Celiac Disease. Nutrients 2015, 7, 8733-8751.

AMA Style

Ciccocioppo R, Kruzliak P, Cangemi GC, Pohanka M, Betti E, Lauret E, Rodrigo L. The Spectrum of Differences between Childhood and Adulthood Celiac Disease. Nutrients. 2015; 7(10):8733-8751.

Chicago/Turabian Style

Ciccocioppo, Rachele; Kruzliak, Peter; Cangemi, Giuseppina C.; Pohanka, Miroslav; Betti, Elena; Lauret, Eugenia; Rodrigo, Luis. 2015. "The Spectrum of Differences between Childhood and Adulthood Celiac Disease" Nutrients 7, no. 10: 8733-8751.

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