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Open AccessArticle

Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis

Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110013, China
Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2015, 7(1), 74-90;
Received: 25 September 2014 / Accepted: 12 December 2014 / Published: 29 December 2014
Hyperhomocysteinemia (HHcy, total homocysteine concentrations > 15 μmol/L) has been associated with increased risk of many diseases. A systematic review was performed to summarize the prevalence of HHcy in China. We searched multiple international and Chinese scientific databases for relevant literature, and further manually screened reference lists and corresponded with original authors. Pooled prevalence of HHcy was calculated using random effects model. Subgroup analysis, meta-regression and sensitivity analysis were also performed. A total of 36 studies consisting 60,754 subjects (57.3% male; age range, 3–97 years) were finally included. The overall pooled prevalence of HHcy was 27.5%. Geographically, the prevalence was high in north areas, intermediate in central areas, and low in south areas, and was higher in inland versus coastal areas. The prevalence increased with age and was significantly higher in men than in women. Rural residents had a slightly higher HHcy prevalence than urban residents, and the studies conducted during 2006 to 2012 presented a higher HHcy prevalence than those during 1990 to 2005. In summary, the prevalence of HHcy in China is high, particularly in northern populations, the inlanders, males, and the elderly. Homocysteine-lowering strategies are necessary to reduce this highly preventable disorder. View Full-Text
Keywords: hyperhomocysteinemia; prevalence; China; meta-analysis hyperhomocysteinemia; prevalence; China; meta-analysis
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Yang, B.; Fan, S.; Zhi, X.; Wang, Y.; Wang, Y.; Zheng, Q.; Sun, G. Prevalence of Hyperhomocysteinemia in China: A Systematic Review and Meta-Analysis. Nutrients 2015, 7, 74-90.

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