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Nutrients 2014, 6(9), 3942-3967;

GI Symptoms in Infants Are a Potential Target for Fermented Infant Milk Formulae: A Review

Nutricia Research, Early Life Nutrition, P.O. Box 80141, 3508 TC Utrecht, The Netherlands
Department of Pediatric Gastroenterology-Hepatology and Nutrition, Necker Children's Hospital, University of Paris, 75015 Paris, France
Author to whom correspondence should be addressed.
Received: 15 July 2014 / Revised: 28 August 2014 / Accepted: 9 September 2014 / Published: 25 September 2014
Full-Text   |   PDF [237 KB, uploaded 25 September 2014]


Besides pre- and pro-biotic-containing infant formulae, fermented infant formulae are commonly used to relieve or prevent symptoms of gastrointestinal (GI) discomfort in young infants. During the fermentation process in cow’s milk-based formulae, the beneficial bacteria modulate the product by forming several beneficial compounds, which contribute to the alleviation of the symptoms observed. This review summarizes the clinical evidence on the impact of fermented infant formulae on common pediatric GI-symptoms. The potential mechanisms involved are discussed: i.e., the lactose and protein (in-) digestibility, effects on gastric emptying and gut transit and modulation of the colonic microbiota. Although initial evidence indicates a beneficial effect of fermented formulae on GI discomfort in newborns, validation and confirmation of the clinical proof obtained so far is warranted, as well as further research to (more fully) understand the mode of action. View Full-Text
Keywords: infant milk formula; fermentation; GI function; GI symptoms infant milk formula; fermentation; GI function; GI symptoms
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

van de Heijning, B.J.M.; Berton, A.; Bouritius, H.; Goulet, O. GI Symptoms in Infants Are a Potential Target for Fermented Infant Milk Formulae: A Review. Nutrients 2014, 6, 3942-3967.

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