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Nutrients 2014, 6(8), 3117-3129;

Normal Roles for Dietary Fructose in Carbohydrate Metabolism

Division of Diabetes, Endocrine and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 6707 Democracy Blvd, Room 787, MSC 5460, Bethesda, MD 20892, USA
Received: 11 June 2014 / Revised: 16 July 2014 / Accepted: 24 July 2014 / Published: 5 August 2014
(This article belongs to the Special Issue Sugar and Obesity)
Full-Text   |   PDF [194 KB, uploaded 5 August 2014]


Although there are many well-documented metabolic effects linked to the fructose component of a very high sugar diet, a healthy diet is also likely to contain appreciable fructose, even if confined to that found in fruits and vegetables. These normal levels of fructose are metabolized in specialized pathways that synergize with glucose at several metabolic steps. Glucose potentiates fructose absorption from the gut, while fructose catalyzes glucose uptake and storage in the liver. Fructose accelerates carbohydrate oxidation after a meal. In addition, emerging evidence suggests that fructose may also play a role in the secretion of insulin and GLP-1, and in the maturation of preadipocytes to increase fat storage capacity. Therefore, fructose undergoing its normal metabolism has the interesting property of potentiating the disposal of a dietary carbohydrate load through several routes. View Full-Text
Keywords: fructose; carbohydrate; metabolism; liver fructose; carbohydrate; metabolism; liver
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Laughlin, M.R. Normal Roles for Dietary Fructose in Carbohydrate Metabolism. Nutrients 2014, 6, 3117-3129.

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