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Article

Randomized Controlled Trial Examining the Effects of Fish Oil and Multivitamin Supplementation on the Incorporation of n-3 and n-6 Fatty Acids into Red Blood Cells

1
Centre for Human Psychopharmacology, Swinburne University of Technology, P.O. Box 218, Hawthorn 3122, Australia
2
Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton VIC 3800, Australia
3
Metabolic Research Unit, School of Medicine, Deakin University, Melbourne 3216, Australia
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NatMed-Research Unit, Southern Cross University, Lismore NSW 2480, Australia
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School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia
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National Institute of Integrative Medicine, Hawthorn 3122, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2014, 6(5), 1956-1970; https://doi.org/10.3390/nu6051956
Received: 28 February 2014 / Revised: 23 April 2014 / Accepted: 30 April 2014 / Published: 14 May 2014
The present randomized, placebo-controlled, double-blind, parallel-groups clinical trial examined the effects of fish oil and multivitamin supplementation on the incorporation of n-3 and n-6 fatty acids into red blood cells. Healthy adult humans (n = 160) were randomized to receive 6 g of fish oil, 6 g of fish oil plus a multivitamin, 3 g of fish oil plus a multivitamin or a placebo daily for 16 weeks. Treatment with 6 g of fish oil, with or without a daily multivitamin, led to higher eicosapentaenoic acid (EPA) composition at endpoint. Docosahexaenoic acid (DHA) composition was unchanged following treatment. The long chain LC n-3 PUFA index was only higher, compared to placebo, in the group receiving the combination of 6 g of fish oil and the multivitamin. Analysis by gender revealed that all treatments increased EPA incorporation in females while, in males, EPA was only significantly increased by the 6 g fish oil multivitamin combination. There was considerable individual variability in the red blood cell incorporation of EPA and DHA at endpoint. Gender contributed to a large proportion of this variability with females generally showing higher LC n-3 PUFA composition at endpoint. In conclusion, the incorporation of LC n-3 PUFA into red blood cells was influenced by dosage, the concurrent intake of vitamin/minerals and gender. View Full-Text
Keywords: fish oils; multivitamins; n-3; randomized; controlled trial (RCT); fatty acid; diet fish oils; multivitamins; n-3; randomized; controlled trial (RCT); fatty acid; diet
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MDPI and ACS Style

Pipingas, A.; Cockerell, R.; Grima, N.; Sinclair, A.; Stough, C.; Scholey, A.; Myers, S.; Croft, K.; Sali, A.; Pase, M.P. Randomized Controlled Trial Examining the Effects of Fish Oil and Multivitamin Supplementation on the Incorporation of n-3 and n-6 Fatty Acids into Red Blood Cells. Nutrients 2014, 6, 1956-1970. https://doi.org/10.3390/nu6051956

AMA Style

Pipingas A, Cockerell R, Grima N, Sinclair A, Stough C, Scholey A, Myers S, Croft K, Sali A, Pase MP. Randomized Controlled Trial Examining the Effects of Fish Oil and Multivitamin Supplementation on the Incorporation of n-3 and n-6 Fatty Acids into Red Blood Cells. Nutrients. 2014; 6(5):1956-1970. https://doi.org/10.3390/nu6051956

Chicago/Turabian Style

Pipingas, Andrew, Robyn Cockerell, Natalie Grima, Andrew Sinclair, Con Stough, Andrew Scholey, Stephen Myers, Kevin Croft, Avni Sali, and Matthew P. Pase. 2014. "Randomized Controlled Trial Examining the Effects of Fish Oil and Multivitamin Supplementation on the Incorporation of n-3 and n-6 Fatty Acids into Red Blood Cells" Nutrients 6, no. 5: 1956-1970. https://doi.org/10.3390/nu6051956

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