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Open AccessArticle

Caffeine Intake May Modulate Inflammation Markers in Trained Rats

Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil
Laboratório de Bioquímica do Exercício (BioEx), Centro de Educação Física e Desportos, Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil
Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, 4810101, Temuco, Chile
Departamento de Neuropsiquiatria, Centro de Ciências da Saúde (CCS), Universidade Federal de Santa Maria (UFSM), 97105-900 Santa Maria, Brazil
Author to whom correspondence should be addressed.
Nutrients 2014, 6(4), 1678-1690;
Received: 28 February 2014 / Revised: 19 March 2014 / Accepted: 25 March 2014 / Published: 21 April 2014
(This article belongs to the Special Issue Sport and Performance Nutrition)
PDF [593 KB, uploaded 21 April 2014]


Caffeine is presented in many commercial products and has been proven to induce ergogenic effects in exercise, mainly related to redox status homeostasis, inflammation and oxidative stress-related adaptation mechanisms. However, most studies have mainly focused on muscle adaptations, and the role of caffeine in different tissues during exercise training has not been fully described. The aim of this study was therefore, to analyze the effects of chronic caffeine intake and exercise training on liver mitochondria functioning and plasma inflammation markers. Rats were divided into control, control/caffeine, exercise, and exercise/caffeine groups. Exercise groups underwent four weeks of swimming training and caffeine groups were supplemented with 6 mg/kg/day. Liver mitochondrial swelling and complex I activity, and plasma myeloperoxidase (MPO) and acetylcholinesterase (AChE) activities were measured. An anti-inflammatory effect of exercise was evidenced by reduced plasma MPO activity. Additionally, caffeine intake alone and combined with exercise decreased the plasma AChE and MPO activities. The per se anti-inflammatory effect of caffeine intake should be highlighted considering its widespread use as an ergogenic aid. Therefore, caffeine seems to interfere on exercise-induced adaptations and could also be used in different exercise-related health treatments. View Full-Text
Keywords: caffeine; exercise training; mitochondria; inflammation; myeloperoxidase caffeine; exercise training; mitochondria; inflammation; myeloperoxidase

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Barcelos, R.P.; Souza, M.A.; Amaral, G.P.; Stefanello, S.T.; Bresciani, G.; Fighera, M.R.; Soares, F.A.A.; De Vargas Barbosa, N. Caffeine Intake May Modulate Inflammation Markers in Trained Rats. Nutrients 2014, 6, 1678-1690.

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