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The Role for Dietary Omega-3 Fatty Acids Supplementation in Older Adults

Department of Clinical Medicine Sapienza, University of Rome, Viale dell'Università 37, 00185 Rome, Italy
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These authors contributed equally to this work.
Nutrients 2014, 6(10), 4058-4072; https://doi.org/10.3390/nu6104058
Received: 10 March 2014 / Revised: 28 August 2014 / Accepted: 17 September 2014 / Published: 3 October 2014
(This article belongs to the Special Issue Nutritional Influences on Age-Related Frailty)
Optimal nutrition is one of the most important determinants of healthier ageing, reducing the risk of disability, maintaining mental and physical functions, and thus preserving and ensuring a better quality of life. Dietary intake and nutrient absorption decline with age, thus increasing the risk of malnutrition, morbidity and mortality. Specific nutrients, particularly long-chain omega-3 polyunsaturated fatty acids (PUFAs), might have the potential of preventing and reducing co-morbidities in older adults. Omega-3 PUFAs are able to modulate inflammation, hyperlipidemia, platelet aggregation, and hypertension. Different mechanisms contribute to these effects, including conditioning cell membrane function and composition, eicosanoid production, and gene expression. The present review analyzes the influence of omega-3 PUFAs status and intake on brain function, cardiovascular system, immune function, muscle performance and bone health in older adults. Omega-3 FAs may have substantial benefits in reducing the risk of cognitive decline in older people. The available data encourage higher intakes of omega-3 PUFAs in the diet or via specific supplements. More studies are needed to confirm the role of omega-3 FAs in maintaining bone health and preventing the loss of muscle mass and function associated with ageing. In summary, omega-3 PUFAs are now identified as potential key nutrients, safe and effective in the treatment and prevention of several negative consequences of ageing. View Full-Text
Keywords: omega-3 fatty acids; eicosapentaenoic acid; docosapentaenoic acid; docosahexaenoic acid; older adults. omega-3 fatty acids; eicosapentaenoic acid; docosapentaenoic acid; docosahexaenoic acid; older adults.
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Molfino, A.; Gioia, G.; Fanelli, F.R.; Muscaritoli, M. The Role for Dietary Omega-3 Fatty Acids Supplementation in Older Adults. Nutrients 2014, 6, 4058-4072.

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