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Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions

Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Via GB Grassi 74, Milan I-20157, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Commenda 10, Milan I-20157, Italy
Author to whom correspondence should be addressed.
Nutrients 2013, 5(8), 3022-3033;
Received: 18 June 2013 / Revised: 14 July 2013 / Accepted: 22 July 2013 / Published: 31 July 2013
(This article belongs to the Special Issue Dietary Magnesium and Human Health)
PDF [456 KB, uploaded 31 July 2013]


A tight control of magnesium homeostasis seems to be crucial for bone health. On the basis of experimental and epidemiological studies, both low and high magnesium have harmful effects on the bones. Magnesium deficiency contributes to osteoporosis directly by acting on crystal formation and on bone cells and indirectly by impacting on the secretion and the activity of parathyroid hormone and by promoting low grade inflammation. Less is known about the mechanisms responsible for the mineralization defects observed when magnesium is elevated. Overall, controlling and maintaining magnesium homeostasis represents a helpful intervention to maintain bone integrity. View Full-Text
Keywords: osteoporosis; magnesium; osteoblast; osteoclast osteoporosis; magnesium; osteoblast; osteoclast

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Castiglioni, S.; Cazzaniga, A.; Albisetti, W.; Maier, J.A.M. Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions. Nutrients 2013, 5, 3022-3033.

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