Next Article in Journal
Vitamin D Insufficiency and Bone Mineral Status in a Population of Newcomer Children in Canada
Next Article in Special Issue
Body Fat Distribution and Insulin Resistance
Previous Article in Journal
Homocysteine Lowering by Folate-Rich Diet or Pharmacological Supplementations in Subjects with Moderate Hyperhomocysteinemia
Previous Article in Special Issue
Dyslipidemia in Obesity: Mechanisms and Potential Targets
 
Search for Articles:
Title / Keyword
Author / Affiliation
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
Journals
Nutrients
Volume 5
Issue 5
10.3390/nu5051544
nutrients-logo
Submit to this Journal Review for this Journal Edit a Special Issue
► Article Menu

Article Menu

share announcement thumb_up
...
textsms
...
Open AccessReview

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

by
Melania Gaggini
1,
Mariangela Morelli
1,
Emma Buzzigoli
1,
Ralph A. DeFronzo
2,
Elisabetta Bugianesi
3 and
Amalia Gastaldelli
1,2,*
1
Institute of Clinical Physiology National Research Council, Pisa 56100, Italy
2
Division of Diabetes, University of Texas Health Science Center, San Antonio, TX 78229, USA
3
Department of Medical Sciences, Division of Gastro-Hepatology, San Giovanni Battista Hospital, University of Turin, Turin 10126, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2013, 5(5), 1544-1560; https://doi.org/10.3390/nu5051544
Received: 25 February 2013 / Revised: 12 April 2013 / Accepted: 16 April 2013 / Published: 10 May 2013
(This article belongs to the Special Issue Dyslipidemia and Obesity)
View Full-Text Download PDF
Browse Figures

Abstract

Non-alcoholic fatty liver disease is marked by hepatic fat accumulation not due to alcohol abuse. Several studies have demonstrated that NAFLD is associated with insulin resistance leading to a resistance in the antilipolytic effect of insulin in the adipose tissue with an increase of free fatty acids (FFAs). The increase of FFAs induces mitochondrial dysfunction and development of lipotoxicity. Moreover, in subjects with NAFLD, ectopic fat also accumulates as cardiac and pancreatic fat. In this review we analyzed the mechanisms that relate NAFLD with metabolic syndrome and dyslipidemia and its association with the development and progression of cardiovascular disease. View Full-Text
Keywords: non-alcoholic fatty liver (NAFLD); steatosis; visceral fat; lipotoxicity; insulin resistance; free fatty acids; dyslipidemia; cardiometabolic risk non-alcoholic fatty liver (NAFLD); steatosis; visceral fat; lipotoxicity; insulin resistance; free fatty acids; dyslipidemia; cardiometabolic risk
►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License
SciFeed

Share and Cite

MDPI and ACS Style

Gaggini, M.; Morelli, M.; Buzzigoli, E.; DeFronzo, R.A.; Bugianesi, E.; Gastaldelli, A. Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease. Nutrients 2013, 5, 1544-1560. https://doi.org/10.3390/nu5051544

AMA Style

Gaggini M, Morelli M, Buzzigoli E, DeFronzo RA, Bugianesi E, Gastaldelli A. Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease. Nutrients. 2013; 5(5):1544-1560. https://doi.org/10.3390/nu5051544

Chicago/Turabian Style

Gaggini, Melania; Morelli, Mariangela; Buzzigoli, Emma; DeFronzo, Ralph A.; Bugianesi, Elisabetta; Gastaldelli, Amalia. 2013. "Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease" Nutrients 5, no. 5: 1544-1560. https://doi.org/10.3390/nu5051544

Find Other Styles

Article Metrics

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop