Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease
Abstract
:1. Introduction
2. Insulin Resistance and the Development of NAFLD
3. Impact of Hepatic and Visceral Fat Accumulation on Metabolic Profile
Group of subjects | IHTG (%) | VF | Reference | |
---|---|---|---|---|
Matched on VAT | Normal IHTG | 3.6 ± 0.5 | 1.29 ± 0.24 kg | [12] |
High IHTG | 25.3 ± 3.5 | 1.34 ± 0.18 kg | ||
Matched on IHTG | Low VF | 13.2 ± 3.5 | 0.76 ± 0.08 kg | [12] |
High VF | 13.2 ± 3.3 | 1.94 ± 0.32 kg | ||
Low IH-TG | Low VF | 2.1 ± 0.6 | 70 ± 8 cm2 | [7] |
High VF | 12.9 ± 1.9 | 84 ± 5 cm2 | ||
High IH-TG | Low VF | 3.2 ± 1.6 | 165 ± 41 cm2 | [7] |
High VF | 23.3 ± 1.7 | 159 ± 9 cm2 |
4. Fatty Liver, Dyslipidemia and the Metabolic Syndrome
Fatty Liver and Metabolic Syndrome
5. NAFLD and Cardiovascular Disease
5.1. Fatty Liver and Atherosclerosis
5.2. Fatty Liver and Endothelial Dysfunction
5.3. Fatty Liver and Coronary Artery Disease (CAD)
6. Conclusions
Acknowledgments
Conflict of Interest
References
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Gaggini, M.; Morelli, M.; Buzzigoli, E.; DeFronzo, R.A.; Bugianesi, E.; Gastaldelli, A. Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease. Nutrients 2013, 5, 1544-1560. https://doi.org/10.3390/nu5051544
Gaggini M, Morelli M, Buzzigoli E, DeFronzo RA, Bugianesi E, Gastaldelli A. Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease. Nutrients. 2013; 5(5):1544-1560. https://doi.org/10.3390/nu5051544
Chicago/Turabian StyleGaggini, Melania, Mariangela Morelli, Emma Buzzigoli, Ralph A. DeFronzo, Elisabetta Bugianesi, and Amalia Gastaldelli. 2013. "Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease" Nutrients 5, no. 5: 1544-1560. https://doi.org/10.3390/nu5051544