Next Article in Journal
Breastfeeding Promotion, Support and Protection: Review of Six Country Programmes
Next Article in Special Issue
Body-Related Social Comparison and Disordered Eating among Adolescent Females with an Eating Disorder, Depressive Disorder, and Healthy Controls
Previous Article in Journal
Pre-Exercise Hyperhydration-Induced Bodyweight Gain Does Not Alter Prolonged Treadmill Running Time-Trial Performance in Warm Ambient Conditions
Previous Article in Special Issue
A Community-Based Study of Enduring Eating Features in Young Women
Article Menu

Export Article

Open AccessReview

The Role of Ghrelin, Salivary Secretions, and Dental Care in Eating Disorders

Department of Orthodontics, Medical and Dental Hospital, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Department of Orthodontics and Dentofacial Orthopedics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan
Author to whom correspondence should be addressed.
Nutrients 2012, 4(8), 967-989;
Received: 12 June 2012 / Revised: 16 July 2012 / Accepted: 2 August 2012 / Published: 13 August 2012
(This article belongs to the Special Issue Maladaptive Eating Attitudes in Youth)
PDF [889 KB, uploaded 13 August 2012]


Eating disorders, including anorexia and bulimia nervosa, are potentially life-threatening syndromes characterized by severe disturbances in eating behavior. An effective treatment strategy for these conditions remains to be established, as patients with eating disorders tend to suffer from multiple relapses. Because ghrelin was originally discovered in the stomach mucosa, it has been widely studied over the past decade in an effort to uncover its potential roles; these studies have shed light on the mechanism by which ghrelin regulates food intake. Thus, studying ghrelin in the context of eating disorders could improve our understanding of the pathogenesis of eating disorders, possibly resulting in a promising new pharmacological treatment strategy for these patients. In addition, early detection and treatment of eating disorders are critical for ensuring recovery of young patients. Oral symptoms, including mucosal, dental, and saliva abnormalities, are typically observed in the early stages of eating disorders. Although oral care is not directly related to the treatment of eating disorders, knowledge of the oral manifestations of eating disorder patients may aid in early detection, resulting in earlier treatment; thus, oral care might contribute to overall patient management and prognosis. Moreover, ghrelin has also been found in saliva, which may be responsible for oral hygiene and digestion-related functions. This review discusses the pharmacological potential of ghrelin in regulating food-intake and the role of saliva and oral care in young patients with eating disorders. View Full-Text
Keywords: anorexia nervosa; bulimia nervosa; ghrelin; salivary secretions anorexia nervosa; bulimia nervosa; ghrelin; salivary secretions

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Yagi, T.; Ueda, H.; Amitani, H.; Asakawa, A.; Miyawaki, S.; Inui, A. The Role of Ghrelin, Salivary Secretions, and Dental Care in Eating Disorders. Nutrients 2012, 4, 967-989.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top