Next Article in Journal
When Food Meets Man: the Contribution of Epigenetics to Health
Next Article in Special Issue
Vitamin D and Bone Health; Potential Mechanisms
Previous Article in Journal
Beliefs and Attitudes toward Vegetarian Lifestyle across Generations
Previous Article in Special Issue
The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status
Open AccessReview

Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA
Nutrients 2010, 2(5), 532-550; https://doi.org/10.3390/nu2050532
Received: 25 March 2010 / Revised: 7 May 2010 / Accepted: 18 May 2010 / Published: 25 May 2010
(This article belongs to the Special Issue Feature Papers for Vitamins)
Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the experimental models used, the vitamin A-deficient avian embryo has been an important tool to study the function of vitamin A during early heart formation. A cluster of retinoic acid-regulated developmental genes have been identified that participate in building the heart. In the absence of retinoic acid the embryonic heart develops abnormally leading to embryolethality. View Full-Text
Keywords: vitamin A-deficient; quail embryo; retinoic acid; gene regulation; heart morphogenesis vitamin A-deficient; quail embryo; retinoic acid; gene regulation; heart morphogenesis
Show Figures

Figure 1

MDPI and ACS Style

Zile, M.H. Vitamin A–Not for Your Eyes Only: Requirement for Heart Formation Begins Early in Embryogenesis. Nutrients 2010, 2, 532-550.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop