Next Article in Journal
Sea Vegetables and Fruits as Novel Dietary Protective Factors for Sarcopenia and Muscle Function in Taiwan: A Cross-Sectional Study
Previous Article in Journal
The Gut Nexus: Unraveling Microbiota-Mediated Links Between Type 2 Diabetes and Colorectal Cancer
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 17
Issue 23
10.3390/nu17233804
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Oral Supplementation with Prunus domestica L. Extract Restores Recognition Memory Impairment Caused by D-Galactose in Rats

by
Anusara Aranarochana
1,2,
Puncharatsm Pannin
1,2,
Papatchaya Sintow
1,2,
Apiwat Sirichoat
1,2,
Nataya Sritawan
1,2,
Wanassanan Pannangrong
1,
Rawiwan Charoensup
3,4,
Wuttichai Jaidee
3,
Piti Ungarreevittaya
5,
Peter Wigmore
6 and
Jariya Umka Welbat
1,2,*
1
Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
2
Neurogenesis Research Group, Khon Kaen University, Khon Kaen 40002, Thailand
3
Medicinal Plant Innovation Center of Mae Fah Luang University, Mae Fah Luang University, Chiang Rai 57100, Thailand
4
School of Integrative Medicine, Mae Fah Luang University, Chiang Rai 57100, Thailand
5
Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
6
School of Life Sciences, Medical School, Queen’s Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(23), 3804; https://doi.org/10.3390/nu17233804 (registering DOI)
Submission received: 8 November 2025 / Revised: 30 November 2025 / Accepted: 3 December 2025 / Published: 4 December 2025
(This article belongs to the Section Nutrition and Neuro Sciences)
Versions Notes

Abstract

Background/Objectives: Aging-related cognitive decline, linked to oxidative stress and impaired hippocampal neurogenesis, is a major contributor to neurodegenerative disorders. In rodents, this condition can be modeled by D-galactose (D-gal) administration, which induces oxidative stress and recognition memory deficits. Prunus domestica L. (PD), rich in phenolic and flavonoid compounds with antioxidant properties, may counteract such impairments. This study evaluated the effects of PD extract on D-gal-induced memory decline by analyzing its phytochemical content, antioxidant activity, and neuroprotective potential. Methods: Phytochemicals were quantified by colorimetric and pH differential methods, and antioxidant capacity was determined using DPPH and FRAP assays. Male Sprague Dawley rats (12 weeks; n = 12/group) were assigned to 8 groups: vehicle, D-gal, PD (75, 100, or 150 mg/kg), and D-gal + PD (same respective doses). D-gal (50 mg/kg, i.p.) and/or PD were administered by oral gavage daily for 8 weeks. Recognition memory was assessed by the novel object recognition (NOR) test. Hippocampal tissues were processed for immunofluorescence staining of the proliferation marker Ki-67 and superoxide dismutase (SOD) activity using the cytochrome C reduction method. Results: PD extract contained abundant phenolics, tannins, flavonoids, and anthocyanins, and exhibited notable antioxidant activity. D-gal impaired recognition memory, reduced hippocampal cell proliferation, and decreased SOD activity. Co-treatment with PD improved memory performance, enhanced hippocampal neurogenesis, and restored antioxidant enzyme activity. Conclusions: PD extract may protect against D-gal-induced age-related cognitive decline through antioxidant effects and support of hippocampal neurogenesis.
Keywords: Prunus domestica L.; phytochemical contents; antioxidant activity; D-galactose; memory impairment; hippocampal neurogenesis Prunus domestica L.; phytochemical contents; antioxidant activity; D-galactose; memory impairment; hippocampal neurogenesis

Share and Cite

MDPI and ACS Style

Aranarochana, A.; Pannin, P.; Sintow, P.; Sirichoat, A.; Sritawan, N.; Pannangrong, W.; Charoensup, R.; Jaidee, W.; Ungarreevittaya, P.; Wigmore, P.; et al. Oral Supplementation with Prunus domestica L. Extract Restores Recognition Memory Impairment Caused by D-Galactose in Rats. Nutrients 2025, 17, 3804. https://doi.org/10.3390/nu17233804

AMA Style

Aranarochana A, Pannin P, Sintow P, Sirichoat A, Sritawan N, Pannangrong W, Charoensup R, Jaidee W, Ungarreevittaya P, Wigmore P, et al. Oral Supplementation with Prunus domestica L. Extract Restores Recognition Memory Impairment Caused by D-Galactose in Rats. Nutrients. 2025; 17(23):3804. https://doi.org/10.3390/nu17233804

Chicago/Turabian Style

Aranarochana, Anusara, Puncharatsm Pannin, Papatchaya Sintow, Apiwat Sirichoat, Nataya Sritawan, Wanassanan Pannangrong, Rawiwan Charoensup, Wuttichai Jaidee, Piti Ungarreevittaya, Peter Wigmore, and et al. 2025. "Oral Supplementation with Prunus domestica L. Extract Restores Recognition Memory Impairment Caused by D-Galactose in Rats" Nutrients 17, no. 23: 3804. https://doi.org/10.3390/nu17233804

APA Style

Aranarochana, A., Pannin, P., Sintow, P., Sirichoat, A., Sritawan, N., Pannangrong, W., Charoensup, R., Jaidee, W., Ungarreevittaya, P., Wigmore, P., & Welbat, J. U. (2025). Oral Supplementation with Prunus domestica L. Extract Restores Recognition Memory Impairment Caused by D-Galactose in Rats. Nutrients, 17(23), 3804. https://doi.org/10.3390/nu17233804

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Article metric data becomes available approximately 24 hours after publication online.
Back to TopTop