Choline Supplementation Does Not Promote Atherosclerosis in CETP-Expressing Male Apolipoprotein E Knockout Mice
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Plasma Analysis of Trimethylamine N-Oxide
2.3. Lipoprotein Plasma Profiling
2.4. HDL Inflammatory Index (HII)
2.5. Measurement of Plasma Myeloperoxidase and Oxidized Phospholipids
2.6. Assessment of Atherosclerosis
2.7. Statistical Analysis
3. Results
3.1. In Vivo Plasma Levels of TMAO
3.2. Lack of TMAO Effect on Aortic Lesions
3.3. Effects of Increased TMAO on Plasma Lipid Profile
3.4. Effects of TMAO on MPO, OxLDL and HDL Antioxidant Capacity
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Collins, H.L.; Adelman, S.J.; Butteiger, D.N.; Bortz, J.D. Choline Supplementation Does Not Promote Atherosclerosis in CETP-Expressing Male Apolipoprotein E Knockout Mice. Nutrients 2022, 14, 1651. https://doi.org/10.3390/nu14081651
Collins HL, Adelman SJ, Butteiger DN, Bortz JD. Choline Supplementation Does Not Promote Atherosclerosis in CETP-Expressing Male Apolipoprotein E Knockout Mice. Nutrients. 2022; 14(8):1651. https://doi.org/10.3390/nu14081651
Chicago/Turabian StyleCollins, Heidi L., Steven J. Adelman, Dustie N. Butteiger, and Jonathan D. Bortz. 2022. "Choline Supplementation Does Not Promote Atherosclerosis in CETP-Expressing Male Apolipoprotein E Knockout Mice" Nutrients 14, no. 8: 1651. https://doi.org/10.3390/nu14081651