Effect of Probiotic Bifidobacterium bifidum TMC3115 Supplementation on Psychosocial Stress Using a Sub-Chronic and Mild Social Defeat Stress in Mice

Yoda, Kazutoyo; Harata, Gaku; Sato, Mizuho; Miyazawa, Kenji; Ohsawa, Natsuki; He, Fang; Toyoda, Atsushi

doi:10.3390/nu14050970

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Effect of Probiotic Bifidobacterium bifidum TMC3115 Supplementation on Psychosocial Stress Using a Sub-Chronic and Mild Social Defeat Stress in Mice

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Technical Research Laboratory, Takanashi Milk Products Co., Ltd., 5 Honjuku-cho, Asahi-ku, Yokohama 241-0023, Japan

College of Agriculture, Ibaraki University, 3-21-1 Chuo, Ami, Inashiki 300-0393, Japan

United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, 3-8-1 Harumi-cho, Fuchu, Tokyo 183-8509, Japan

Author to whom correspondence should be addressed.

Academic Editor: Miguel Romero Pérez

Nutrients 2022, 14(5), 970; https://doi.org/10.3390/nu14050970

Received: 15 January 2022 / Revised: 23 February 2022 / Accepted: 23 February 2022 / Published: 24 February 2022

(This article belongs to the Section Prebiotics and Probiotics)

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Abstract

With the accumulation of knowledge on the relation between psychological stress and gut microbiota, there is growing interest in controlling stress and/or mood disorders via probiotic supplementation. We aimed to examine the effect of probiotic Bifidobacterium bifidum TMC3115 (TMC3115) supplementation using a sub-chronic and mild social defeat stress murine model in this study. TM3115 supplementation maintained body weight gain and alleviated a polydipsia-like symptom induced by the stress. In the analyses of fecal and cecal bacterial profiles, expansions of Proteobacteria in stressed mice and increases in Actinobacteria and Bifidobacterium in mice supplemented with TMC3115 were observed. There was no marked difference in the diversity of cecal bacteria between the tested mice. Elevated serum levels of inflammatory markers such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 were observed in the stressed mice, while TMC3115 only reduced the IL-6 level. These findings suggest that TMC3115 supplementation confers tolerance to psychosocial stress in the host through modulation of the gut microbiota and alleviation of stress-induced inflammatory responses. Furthermore, it may be expected to exert prevention and treatment of disorders related to peripheral IL-6, including depression. View Full-Text

Keywords: Bifidobacterium; probiotics; stress; interleukin-6

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Yoda, K.; Harata, G.; Sato, M.; Miyazawa, K.; Ohsawa, N.; He, F.; Toyoda, A. Effect of Probiotic Bifidobacterium bifidum TMC3115 Supplementation on Psychosocial Stress Using a Sub-Chronic and Mild Social Defeat Stress in Mice. Nutrients 2022, 14, 970. https://doi.org/10.3390/nu14050970

AMA Style

Yoda K, Harata G, Sato M, Miyazawa K, Ohsawa N, He F, Toyoda A. Effect of Probiotic Bifidobacterium bifidum TMC3115 Supplementation on Psychosocial Stress Using a Sub-Chronic and Mild Social Defeat Stress in Mice. Nutrients. 2022; 14(5):970. https://doi.org/10.3390/nu14050970

Chicago/Turabian Style

Yoda, Kazutoyo, Gaku Harata, Mizuho Sato, Kenji Miyazawa, Natsuki Ohsawa, Fang He, and Atsushi Toyoda. 2022. "Effect of Probiotic Bifidobacterium bifidum TMC3115 Supplementation on Psychosocial Stress Using a Sub-Chronic and Mild Social Defeat Stress in Mice" Nutrients 14, no. 5: 970. https://doi.org/10.3390/nu14050970

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Effect of Probiotic Bifidobacterium bifidum TMC3115 Supplementation on Psychosocial Stress Using a Sub-Chronic and Mild Social Defeat Stress in Mice

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