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Fructooligosaccharide Reduces Weanling Pig Diarrhea in Conjunction with Improving Intestinal Antioxidase Activity and Tight Junction Protein Expression

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
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Academic Editor: Armin Alaedini
Nutrients 2022, 14(3), 512; https://doi.org/10.3390/nu14030512
Received: 9 January 2022 / Revised: 20 January 2022 / Accepted: 24 January 2022 / Published: 25 January 2022
(This article belongs to the Section Nutrition and Metabolism)
This study was to illustrate the effects of fructooligosaccharide (FOS) on the antioxidant capacity, intestinal barrier function, and microbial community of weanling pigs. Results showed that FOS reduced the incidence of diarrhea (6.5 vs. 10.8%) of pigs (p < 0.05) but did not affect growth performance when compared with the control group. A diet supplemented with FOS increased ileal mRNA expression of occludin (1.7 vs. 1.0), claudin-1 (1.9 vs. 1.0), claudin-2 (1.8 vs. 1.0), and claudin-4 (1.7 vs. 1.0), as well as colonic mRNA expression of ZO-1 (1.6 vs. 1.0), claudin-1 (1.7 vs. 1.0), occludin (1.9 vs. 1.0), and pBD-1 (1.5 vs. 1.0) when compared with the control group (p < 0.05). FOS supplementation improved the anti-oxidase activity and expression of nuclear factor erythroid-2 related factor 2 (Nrf2), and decreased concentrations of D-lactate (3.05 U/L vs. 2.83 U/L) and TNF-α (59.1 pg/mL vs. 48.0 pg/mL) in the serum when compared with the control group (p < 0.05). In addition, FOS increased Sharpea, Megasphaera, and Bacillus populations in the gut when compared with the control group (p < 0.05). Association analysis indicated that mRNA expression of occludin and claudin-1 in the ileal mucosa were correlated positively with populations of Sharpea and Bacillus (p < 0.05). Furthermore, mRNA expression of occludin and claudin-1 in the colonic mucosa were correlated positively with abundances of Sharpea, Lactobocillus, and Bifidobacterium (p < 0.05). In conclusion, FOS activated Nrf2 signaling and increased the expression of specific tight junction proteins, which were associated with reduced diarrhea incidence. View Full-Text
Keywords: fructooligosaccharide; intestinal barrier; gut microbiota; antioxidant capacity; weanling pigs fructooligosaccharide; intestinal barrier; gut microbiota; antioxidant capacity; weanling pigs
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MDPI and ACS Style

Zhang, Z.; Zhang, G.; Zhang, S.; Zhao, J. Fructooligosaccharide Reduces Weanling Pig Diarrhea in Conjunction with Improving Intestinal Antioxidase Activity and Tight Junction Protein Expression. Nutrients 2022, 14, 512. https://doi.org/10.3390/nu14030512

AMA Style

Zhang Z, Zhang G, Zhang S, Zhao J. Fructooligosaccharide Reduces Weanling Pig Diarrhea in Conjunction with Improving Intestinal Antioxidase Activity and Tight Junction Protein Expression. Nutrients. 2022; 14(3):512. https://doi.org/10.3390/nu14030512

Chicago/Turabian Style

Zhang, Zeyu, Ge Zhang, Shuai Zhang, and Jinbiao Zhao. 2022. "Fructooligosaccharide Reduces Weanling Pig Diarrhea in Conjunction with Improving Intestinal Antioxidase Activity and Tight Junction Protein Expression" Nutrients 14, no. 3: 512. https://doi.org/10.3390/nu14030512

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