The Impact of Prebiotic, Probiotic, and Synbiotic Supplements and Yogurt Consumption on the Risk of Colorectal Neoplasia among Adults: A Systematic Review

Round 1

Reviewer 1 Report

The authors present a systematic population-based review over probiotic-type interventions and colorectal neoplasia. A review of this type has not yet been performed. This review covers four groups: prebiotic, probiotic, synbiotic, and yogurt supplementation in adults and if these affect colorectal neoplasia.

As use of probiotic intervention may be chemoprotective, I found this review to be relevant and of interest. It was well written and organized.

Author Response

We are very grateful for the positive review from reviewer one.

Reviewer 2 Report

The manuscript entitled "The Impact of Prebiotic, Probiotic, and Synbiotic Supplements 2 and Yogurt Consumption on the Risk of Colorectal Neoplasia 3 among Adults: A Systematic Review" by kim et al is interesting, but there are some concerns regarding this study. 
The authors only quoted the results of the former studies. However, in order to improve the quality of this paper, the authors should add more studies, including possible reasons or mechanistic studies to elaborate on the reason why the yogurt is inversely associated with colorectal neoplasia. Why not the probiotics or Synbiotic supplementation? Moreover, the conclusion should cover research outcomes, application in other fields/industry/studies, and future perspective.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report

 In the present form the paper is acceptable