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Volume 14
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Article

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice

by
Yacoubou Abdoul Razak Mahaman
1,2,3,†,
Jun Feng
4,†,
Fang Huang
3,
Maibouge Tanko Mahamane Salissou
3,5,
Jianzhi Wang
1,3,6,
Rong Liu
3,
Bin Zhang
3,
Honglian Li
3,
Feiqi Zhu
2,* and
Xiaochuan Wang
1,3,6,7,*
1
Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China
2
Cognitive Impairment Ward of Neurology Department, The Third Affiliated Hospital of Shenzhen University, 47 Youyi Rd., Shenzhen 518001, China
3
Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry and Huibei Province of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
4
Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
5
College of Health, Natural and Agriculture Sciences Africa University, Mutare P.O. Box 1320, Zimbabwe
6
Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China
7
Shenzhen Research Institute, Huazhong University of Science and Technology, Shenzhen 518000, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Nutrients 2022, 14(20), 4284; https://doi.org/10.3390/nu14204284
Submission received: 21 August 2022 / Revised: 10 October 2022 / Accepted: 12 October 2022 / Published: 14 October 2022
(This article belongs to the Special Issue The Impact of Nutrition on Brain Metabolism and Disease)
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Abstract

Alzheimer’s disease is a global public health problem and the most common form of dementia. Due to the failure of many single therapies targeting the two hallmarks, Aβ and Tau, and the multifactorial etiology of AD, there is now more and more interest in nutraceutical agents with multiple effects such as Moringa oleifera (MO) that have strong anti-oxidative, anti-inflammatory, anticholinesterase, and neuroprotective virtues. In this study, we treated APP/PS1 mice with a methanolic extract of MO for four months and evaluated its effect on AD-related pathology in these mice using a multitude of behavioral, biochemical, and histochemical tests. Our data revealed that MO improved behavioral deficits such as anxiety-like behavior and hyperactivity and cognitive, learning, and memory impairments. MO treatment abrogated the Aβ burden to wild-type control mice levels via decreasing BACE1 and AEP and upregulating IDE, NEP, and LRP1 protein levels. Moreover, MO improved synaptic plasticity by improving the decreased GluN2B phosphorylation, the synapse-related proteins PSD95 and synapsin1 levels, the quantity and quality of dendritic spines, and neurodegeneration in the treated mice. MO is a nutraceutical agent with promising therapeutic potential that can be used in the management of AD and other neurodegenerative diseases.
Keywords: Alzheimer’s disease; amyloid beta; synaptic plasticity; cognitive impairment; Moringa oleifera Alzheimer’s disease; amyloid beta; synaptic plasticity; cognitive impairment; Moringa oleifera

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MDPI and ACS Style

Mahaman, Y.A.R.; Feng, J.; Huang, F.; Salissou, M.T.M.; Wang, J.; Liu, R.; Zhang, B.; Li, H.; Zhu, F.; Wang, X. Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice. Nutrients 2022, 14, 4284. https://doi.org/10.3390/nu14204284

AMA Style

Mahaman YAR, Feng J, Huang F, Salissou MTM, Wang J, Liu R, Zhang B, Li H, Zhu F, Wang X. Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice. Nutrients. 2022; 14(20):4284. https://doi.org/10.3390/nu14204284

Chicago/Turabian Style

Mahaman, Yacoubou Abdoul Razak, Jun Feng, Fang Huang, Maibouge Tanko Mahamane Salissou, Jianzhi Wang, Rong Liu, Bin Zhang, Honglian Li, Feiqi Zhu, and Xiaochuan Wang. 2022. "Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice" Nutrients 14, no. 20: 4284. https://doi.org/10.3390/nu14204284

APA Style

Mahaman, Y. A. R., Feng, J., Huang, F., Salissou, M. T. M., Wang, J., Liu, R., Zhang, B., Li, H., Zhu, F., & Wang, X. (2022). Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice. Nutrients, 14(20), 4284. https://doi.org/10.3390/nu14204284

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