Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Population
2.2. Diet, Dietary Assessment and Follow-Up Visits
2.3. Laboratory Measurements
2.4. OxS- and Inflammation-Related Parameters
2.5. DNA Isolation from Blood Samples
2.6. Genotyping
2.7. Quantitative PCR Analysis of Leucocyte Telomere Length (LTL)
2.8. Statistics
3. Results
3.1. Baseline Characteristics according to the SIRT1 SNPs Genotype
3.2. Relationship between the SNP rs7069102 and LTL
3.3. Relationship between the SNP rs7069102 and Inflammation and OxS-Related Parameters
3.4. Effect of Diet on LTL and Inflammation-Related Parameters According to SIRT1 Gene Variants
3.4.1. Patients Randomized to the LF Diet
3.4.2. Patients Randomized to Med Diet
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | LF Diet | Med Diet | ||||
---|---|---|---|---|---|---|
GG | CG + CC | p Value | GG | CG + CC | p Value | |
N | 162 | 171 | 189 | 194 | ||
Men/Women (n) | 134/28 | 145/26 | 0.607 | 164/25 | 151/43 | 0.022 * |
Age (years) | 58.7 ± 8.7 | 59.6 ± 8.1 | 0.329 | 59.3 ± 8.9 | 59.8 ± 9.2 | 0.629 |
Weight (kg) | 85.3 ± 12.8 | 84.5 ± 12.2 | 0.547 | 86.6 ± 14.2 | 83.7 ± 14 | 0.043 * |
Waist circumference (cm) | 104.5 ± 10.4 | 105.1 ± 10.2 | 0.628 | 105.2 ± 11.5 | 104.1 ± 11 | 0.311 |
BMI (kg/m2) | 31.2 ± 4.3 | 30.7 ± 4 | 0.289 | 31.4 ± 4.4 | 30.9 ± 4.4 | 0.315 |
Total cholesterol (mg/dL) | 157.2± 29.8 | 160.1 ± 28.2 | 0.359 | 158.5 ± 33.1 | 159.6 ± 31.5 | 0.723 |
HDL-C (mg/dL) | 42.1 ± 10 | 42.9 ± 10.1 | 0.452 | 42.2 ± 10.3 | 42.1 ± 10.3 | 0.931 |
LDL-C (mg/dL) | 86.8 ± 23.9 | 89.7± 23.5 | 0.281 | 88.2 ± 26.6 | 90.1 ± 25.4 | 0.486 |
TG (mg/dL) | 128 ± 64.4 | 142.2 ± 73.4 | 0.063 | 137.1 ± 71 | 130.1 ± 64.5 | 0.315 |
Glucose (mg/dL) | 108.8 ± 29.5 | 113.4 ± 38.3 | 0.219 | 115.4 ± 40.8 | 111.4 ± 36.3 | 0.316 |
CRP (mg/dL) | 3.6 ± 4.3 | 2.8 ± 3.2 | 0.073 | 2.7 ± 3.7 | 2.8 ± 3.1 | 0.945 |
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Hidalgo-Moyano, C.; Rangel-Zuñiga, O.A.; Gomez-Delgado, F.; Alcala-Diaz, J.F.; Rodriguez-Cantalejo, F.; Yubero-Serrano, E.M.; Torres-Peña, J.D.; Arenas-de Larriva, A.P.; Camargo, A.; Perez-Martinez, P.; et al. Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study. Nutrients 2022, 14, 3789. https://doi.org/10.3390/nu14183789
Hidalgo-Moyano C, Rangel-Zuñiga OA, Gomez-Delgado F, Alcala-Diaz JF, Rodriguez-Cantalejo F, Yubero-Serrano EM, Torres-Peña JD, Arenas-de Larriva AP, Camargo A, Perez-Martinez P, et al. Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study. Nutrients. 2022; 14(18):3789. https://doi.org/10.3390/nu14183789
Chicago/Turabian StyleHidalgo-Moyano, Cristina, Oriol Alberto Rangel-Zuñiga, Francisco Gomez-Delgado, Juan F. Alcala-Diaz, Fernando Rodriguez-Cantalejo, Elena M. Yubero-Serrano, Jose D. Torres-Peña, Antonio P. Arenas-de Larriva, Antonio Camargo, Pablo Perez-Martinez, and et al. 2022. "Diet and SIRT1 Genotype Interact to Modulate Aging-Related Processes in Patients with Coronary Heart Disease: From the CORDIOPREV Study" Nutrients 14, no. 18: 3789. https://doi.org/10.3390/nu14183789